S Boudina, ED Abel - Circulation, 2007 - Am Heart Assoc The prevalence of diabetes mellitus is growing rapidly. It is estimated that globally the number
of adults affected with diabetes will increase from 135 million in 1995 to 300 million by 2025.
1 Patients with diabetes mellitus are at increased risk for cardiovascular diseases. Thus, ... Cited by 140 - Related articles - All 5 versions
- ►sc.edu [PDF] DPY Koonen, JFC Glatz, A Bonen, JJFP Luiken - BBA-Molecular and Cell …, 2005 - Elsevier Cellular long-chain fatty acid (LCFA) uptake constitutes a process that is not yet fully
understood. LCFA uptake likely involves both passive diffusion and protein-mediated
transport. Several lines of evidence support the involvement of a number of plasma ... Cited by 83 - Related articles - All 4 versions
AN Carley, DL Severson - BBA-Molecular and Cell Biology of Lipids, 2005 - Elsevier The metabolic phenotype of hearts has been investigated using rodent models of type 2 diabetes
which exhibit obesity and insulin resistance: db/db and ob/ob mice, and Zucker fatty and ZDF
rats. In general, cardiac fatty acid (FA) utilization is enhanced in type 2 diabetic hearts, ... Cited by 73 - Related articles - All 3 versions
- ►endojournals.org J Buchanan, PK Mazumder, P Hu, G Chakrabarti, MW … - Endocrinology, 2005 - Endocrine Soc Hyperglycemia is associated with altered myocardial substrate use, a condition that has been
hypothesized to contribute to impaired cardiac performance. The goals of this study were to determine
whether changes in cardiac metabolism, gene expression, and function precede or follow ... Cited by 69 - Related articles - BL Direct - All 5 versions
D An, B Rodrigues - American Journal of Physiology- Heart and …, 2006 - Am Physiological Soc In patients with diabetes, an increased risk of symptomatic heart failure usually develops in the
presence of hypertension or ischemic heart disease. However, a predisposition to heart failure
might also reflect the effects of underlying abnormalities in diastolic function that can ... Cited by 67 - Related articles - BL Direct - All 5 versions
JA Hawley - Diabetes/Metabolism Reviews - interscience.wiley.com During the past half-century, there has been a dramatic increase in the incidence of obesity,
insulin resistance and type 2 diabetes. A hallmark feature of these conditions is impaired glucose
tolerance (IGT). Cross-sectional and retrospective epidemiological studies have provided ... Cited by 63 - Related articles - BL Direct - All 4 versions
- ►nih.gov VA Drover, M Ajmal, F Nassir, NO … - Journal of Clinical …, 2005 - Am Soc Clin Investig CD36 mediates the transfer of fatty acids (FAs) across the plasma membranes of muscle and
adipose cells, thus playing an important role in regulating peripheral FA metabolism in vivo. In
the proximal intestine, CD36 is localized in abundant quantities on the apical surface of ... Cited by 45 - Related articles - All 10 versions
- ►nih.gov M Febbraio, RL Silverstein - International Journal of Biochemistry and Cell …, 2007 - Elsevier CD36 is a broadly expressed membrane glycoprotein that acts as a facilitator of fatty acid
uptake, a signaling molecule, and a receptor for a wide range of ligands, including apoptotic
cells, modified forms of low density lipoprotein, thrombospondins, fibrillar β-amyloid, ... Cited by 42 - Related articles - All 3 versions
- ►physiology.org S Boudina, ED Abel - Physiology, 2006 - Am Physiological Soc Diabetes is a worldwide epidemic (112). Cardiovascular disease remains the major cause of
morbidity and mortality in people with diabetes. Epidemiological studies suggest that the prevalence
of heart failure exceeds that which can be accounted for by other risk factors such as ... Cited by 39 - Related articles - BL Direct - All 5 versions
- ►physiology.org A Bonen, XX Han, DDJ Habets, M … - American Journal of …, 2007 - Am Physiological Soc Fatty acid translocase (FAT)/CD36 is involved in regulating the uptake of long-chain fatty acids
into muscle cells. However, the contribution of FAT/CD36 to fatty acid metabolism remains
unknown. We examined the role of FAT/CD36 on fatty acid metabolism in perfused ... Cited by 32 - Related articles - BL Direct - All 7 versions
