- ►endojournals.org J Nigro, N Osman, AM Dart, PJ Little - Endocrine reviews, 2006 - Endocrine Soc In metabolic tissues, insulin signaling via the phosphatidylinositol-3-kinase
pathway leads to glucose uptake so that in insulin resistance a state of
hyperglycemia occurs; other factors such as dyslipidemia and hypertension ... Cited by 100 - Related articles - BL Direct - All 5 versions
G Chinetti-Gbaguidi, JC Fruchart, B Staels - Current Opinion in Pharmacology, 2005 - Elsevier Several conditions and risk factors predispose to cardiovascular disease,
including visceral obesity, type 2 diabetes, insulin resistance, hypertension
and dyslipidemia, and are collectively called the metabolic syndrome. ... Cited by 40 - Related articles - All 2 versions
NM Al-Rasheed, RS Chana, RJ Baines, GB … - Journal of Biological Chemistry, 2004 - ASBMB Peroxisome proliferator-activated receptor (PPAR ) has key roles in the
regulation of adipogenesis, inflammation, and lipid and glucose metabolism.
C-peptide is believed to be inert and without appreciable biological ... Cited by 31 - Related articles - BL Direct - All 9 versions
- ►dvdres.com [PDF] D Walcher, N Marx - Diabetes and Vascular Disease Research, 2004 - dvdres.com Abstract Over the past few years it has been recognised that insulin resistance
(IR) is an independent risk fac- tor for major cardiovascular events. In
addition, IR is associated with other factors such as hypertension, ... Cited by 20 - Related articles - All 8 versions
- ►nih.gov JD Chang, GK Sukhova, P Libby, E Schvartz, … - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences Inflammatory cell activation by chemokines requires intracellular signaling
through phosphoinositide 3-kinase (PI3-kinase) and the PI3-kinase-dependent
protein serine/threonine kinase Akt. Atherosclerosis is a chronic ... Cited by 18 - Related articles - BL Direct - All 11 versions
- ►ahajournals.org D Walcher, C Babiak, P Poletek, S Rosenkranz … - Circulation research, 2006 - Am Heart Assoc Increased levels of C-peptide, a cleavage product of proinsulin, circulate in
patients with insulin resistance and early type 2 diabetes mellitus. Recent data
suggest a potential causal role of C-peptide in atherogenesis by promoting ... Cited by 17 - Related articles - All 7 versions
Y Kobayashi, K Naruse, Y Hamada, E … - Diabetologia, 2005 - Springer Page 1. Diabetologia (2005) 48: 2396–2401 DOI 10.1007/s00125-005-1942-9 ARTICLE
Y. Kobayashi . K. Naruse . Y. Hamada . E. Nakashima . K. Kato . N. Akiyama . ... Cited by 17 - Related articles - BL Direct - All 3 versions
V Cifarelli, P Luppi, HM Tse, J He, J Piganelli … - Atherosclerosis, 2008 - Elsevier Excessive proliferation of vascular smooth muscle cells (VSMCs) is one of the
primary lesions in atherosclerosis development during diabetes. High glucose
triggers VSMC proliferation and initiates activation of the transcription ... Cited by 12 - Related articles - All 21 versions
A Stancoven, DK McGuire - The American Journal of Cardiology, 2007 - Elsevier Patients with type 2 diabetes mellitus are at increased risk for macrovascular
disease complications. Hyperglycemia and atherosclerotic disease clearly are
associated, and biologic intermediates mediated by hyperglycemia exist. Our ... Cited by 7 - Related articles - All 3 versions
