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Scholar Results 1 - 10 of about 26 citing Kubosaki: Targeted disruption of the IA-2β gene causes glucose intolerance and impairs insulin.... (0.09 sec) 

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice


M Nakayama, N Abiru, H Moriyama, N Babaya, … - Nature, 2005 - pubmedcentral.nih.gov
Cited by 227 - Related articles - All 7 versions

Translational mini-review series on type 1 diabetes: systematic analysis of T cell epitopes …


TP Di Lorenzo, M Peakman, BO Roep - Clinical and Experimental Immunology, 2007 - pubmedcentral.nih.gov
T cell epitopes represent the molecular code words through which the adaptive
immune system communicates. In the context of a T cell-mediated autoimmune
disease such as type 1 diabetes, CD4 and CD8 T cell recognition of islet ...
Cited by 43 - Related articles - BL Direct - All 5 versions

Identification of Naturally Processed HLA-A2—Restricted Proinsulin Epitopes by Reverse …

- shouxi.net
Y Hassainya, F Garcia-Pons, R Kratzer, V … - Diabetes, 2005 - Am Diabetes Assoc
Type 1 diabetes is thought to result from the destruction of β-cells by
autoantigen-specific T-cells. Observations in the NOD mouse model suggest that
CD8 + cytotoxic T-cells play an essential role in both the initial ...
Cited by 43 - Related articles - All 6 versions

IA-2, but not IA-2, is induced by ghrelin and inhibits glucose-stimulated insulin secretion

- pnas.org
A Doi, T Shono, M Nishi, H Furuta, H Sasaki, … - Proceedings of the National Academy of Sciences, 2006 - National Acad Sciences
Ghrelin is a newly discovered peptide and an endogenous ligand for growth
hormone (GH) secretagogue (GHS) receptor. It has been shown to possess various
central and peripheral effects, including GH secretion, food intake, and ...
Cited by 17 - Related articles - BL Direct - All 5 versions

Tolerance to proinsulin-2 is due to radioresistant thymic cells

- jimmunol.org
B Faideau, C Lotton, B Lucas, I Tardivel, JF … - The Journal of Immunology, 2006 - Am Assoc Immnol
Proinsulin is a key Ag in type 1 diabetes, but the mechanisms regulating
proinsulin immune tolerance are unknown. We have shown that preproinsulin-2
gene-deficient mice (proins-2 –/– ) are intolerant to proinsulin-2. In ...
Cited by 14 - Related articles - BL Direct - All 5 versions

Dense Core Vesicle Proteins IA-2 and IA-2β


A Kubosaki, S Nakamura, AL Notkins - Diabetes, 2005 - Am Diabetes Assoc
IA-2 and IA-2β are members of the transmembrane protein tyrosine phosphatase
family located in dense core vesicles of neuroendocrine cells, including the
β-cells of pancreatic islets. In the present study, by mating C57BL/6Nci ...
Cited by 12 - Related articles - BL Direct - All 5 versions

Disruption of the Transmembrane Dense Core Vesicle Proteins IA-2 and IA-2 {beta} Causes …

- endojournals.org
A Kubosaki, S Nakamura, A Clark, JF Morris, … - Endocrinology, 2006 - Endocrine Soc
Female infertility is a worldwide problem affecting 10–15% of the population.
The cause of the infertility in many cases is not known. In the present report,
we demonstrate that alterations in two transmembrane structural proteins, ...
Cited by 10 - Related articles - BL Direct - All 5 versions

[PDF] An extended tyrosine-targeting motif for endocytosis and recycling of the dense-core …


C Wasmeier, PV Burgos, T Trudeau, HW … - Traffic, 2005 - assets0.pubget.com
Integral membrane proteins of neuroendocine dense- core vesicles (DCV) appear to
undergo multiple rounds of exocytosis; however, their trafficking and site of
incorporation into nascent DCVs is unclear. Previous studies with phogrin ...
Cited by 10 - Related articles - View as HTML - All 5 versions

[PDF] Protein tyrosine phosphatases: functional inferences from mouse models and human …


WJ Hendriks, A Elson, S Harroch, AW Stoker - FEBS journal, 2008 - assets0.pubget.com
Research on how oncoviruses transform mammalian cells has led to the firm
establishment of the tyrosine- specific phosphorylation of cellular proteins as
a key signalling mechanism to evoke essential cell decisions, for example ...
Cited by 10 - Related articles - View as HTML - BL Direct - All 8 versions

An immunologic homunculus for type 1 diabetes

- nih.gov [PDF] 
D Homann, GS Eisenbarth - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig
Autoimmune diseases such as the diabetes that develops in NOD mice depend on
immunologic recognition of specific autoantigens, but recognition can result in
a pathogenic or protective T cell response. A study by Du et al. in this ...
Cited by 9 - Related articles - BL Direct - All 10 versions


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