S Bonner-Weir, GC Weir - Nature biotechnology, 2005 - nature.com Two major initiatives are under way to correct the -cell deficit of diabetes: one would generate
-cells ex vivo that are suitable for transplantation, and the second would stimulate regeneration
of -cells in the pancreas. Studies of ex vivo expansion suggest that -cells have a potential ... Cited by 175 - Related articles - All 3 versions
- ►physiology.org L Bouwens, I Rooman - Physiological reviews, 2005 - Am Physiological Soc Beta-cell mass regulation represents a critical issue for understanding diabetes, a disease characterized
by a near-absolute (type 1) or relative (type 2) deficiency in the number of pancreatic beta
cells. The number of islet beta cells present at birth is mainly generated by the ... Cited by 118 - Related articles - BL Direct - All 6 versions
- ►rupress.org KV Tarbell, L Petit, X Zuo, P Toy, X Luo, A … - Journal of Experimental …, 2007 - jem.rupress.org Most treatments that prevent autoimmune diabetes in nonobese diabetic (NOD) mice require
intervention at early pathogenic stages, when insulitis is first developing. We tested whether
dendritic cell (DC)–expanded, islet antigen–specific CD4 + CD25 + suppressor T cells ... Cited by 96 - Related articles - BL Direct - All 8 versions
- ►nih.gov M Trucco - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Type 1 diabetes is the result of an autoimmune attack against the insulin-producing β cells of
the endocrine pancreas. Current treatment for patients with type 1 diabetes typically involves
a rigorous and invasive regimen of testing blood glucose levels many times a day along ... Cited by 69 - Related articles - All 9 versions
J Shapiro… - Transplantation, 2005 - journals.lww.com We gratefully acknowledge ongoing support from a Clinical Center for Islet Transplantation Grant
from the Juvenile Diabetes Research Foundation, Capital Health and the Province Wide Services
of the Government of Alberta, the Roberts Fund, the North American Foundation for the ... Cited by 68 - Related articles - BL Direct - All 4 versions
WL Suarez-Pinzon, Y Yan, R Power, SJ Brand, A … - Diabetes, 2005 - Am Diabetes Assoc Combination therapy with epidermal growth factor (EGF) and gastrin induces β-cell regeneration
in rodents with chemically induced diabetes. We investigated whether EGF plus gastrin could
correct hyperglycemia in NOD mice with autoimmune diabetes. Combined treatment with ... Cited by 54 - Related articles - BL Direct - All 5 versions
X Luo, H Yang, IS Kim, F Saint-Hilaire, DA Thomas, … - Transplantation, 2005 - journals.lww.com Transplantation. Wolters Kluwer Health Logo. All Issues. ... Cited by 52 - Related articles - All 5 versions
- ►jimmunol.org K Minamimura, W Gao, T Maki - The Journal of Immunology, 2006 - Am Assoc Immnol Broad T cell depletion has been used as an integral part of treatment in transplantation and autoimmune
diseases. Following depletion, residual T cells undergo homeostatic proliferation and convert
to memory-like T cells. In this study, we investigated the effect of T cell depletion by ... Cited by 45 - Related articles - BL Direct - All 6 versions
R Mussmann, M Geese, F Harder, S Kegel, U … - Journal of Biological …, 2007 - ASBMB Recent developments indicate that the regeneration of beta cell function and mass in patients
with diabetes is possible. A regenerative approach may represent an alternative treatment option
relative to current diabetes therapies that fail to provide optimal glycemic control. Here we ... Cited by 30 - Related articles - All 7 versions
T Maki, R Gottschalk, N Ogawa, AP Monaco - Transplantation, 2005 - journals.lww.com Skip Navigation Links Home > May 15, 2005 - Volume 79 - Issue 9 > Prevention and Cure of
Autoimmune Diabetes in Nonobese Diabe... ... Maki, Takashi; Gottschalk, Rita; Ogawa,
Norihiko; Monaco, Anthony P. ... The Transplant Center, Beth Israel Deaconess Medical ... Cited by 26 - Related articles - All 6 versions
