- ►jhsph.edu [PDF] CM Larsen, M Faulenbach, A Vaag, A Volund, … - The New England journal of medicine, 2007 - nejm.highwire.org Methods In this double-blind, parallel-group trial involving 70 patients with
type 2 diabetes, we randomly assigned 34 patients to receive 100 mg of anakinra
(a recombinant human interleukin-1–receptor antagonist) subcutaneously ... Cited by 138 - Related articles - BL Direct - All 12 versions
H Kolb, T Mandrup-Poulsen - Diabetologia, 2005 - Springer Abstract Subclinical, low-grade systemic inflammation has been observed in
patients with type 2 diabetes and in those at increased risk of the disease.
This may be more than an epiphenomenon. Alleles of genes encoding immune/ ... Cited by 116 - Related articles - BL Direct - All 5 versions
- ►shouxi.net MY Donath, JA Ehses, K Maedler, DM … - Diabetes, 2005 - Am Diabetes Assoc A decrease in the number of functional insulin-producing β-cells contributes to
the pathophysiology of type 2 diabetes. Opinions diverge regarding the relative
contribution of a decrease in β-cell mass versus an intrinsic defect in ... Cited by 85 - Related articles - BL Direct - All 6 versions
K ALEXANDRAKI, C PIPERI, C KALOFOUTIS, … - Annals of the New York Academy of Sciences, 2006 - ingentaconnect.com Population-based studies have shown strong relationship between inflammatory
markers and metabolic disturbances, obesity, and atherosclerosis, whereas
inflammation has been considered as a “common soil” between these ... Cited by 50 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org N Welsh, M Cnop, I Kharroubi, M Bugliani, R … - Diabetes, 2005 - Am Diabetes Assoc Different degrees of β-cell failure and apoptosis are present in type 1 and
type 2 diabetes. It has been recently suggested that high glucose–induced
β-cell apoptosis in type 2 diabetes shares a final common pathway with ... Cited by 40 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org L Shu, NS Sauter, FT Schulthess, AV … - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—To investigate the effects of TCFL7L2 depletion,
isolated islets were exposed to TCF7L2 small interfering RNA (siRNA) versus
scrambled siRNA, and β-cell survival and function were examined. For ... Cited by 37 - Related articles - BL Direct - All 4 versions
- ►ucla.edu [PDF] JJ MEIER, A BHUSHAN, PC BUTLER - Pediatric research, 2006 - journals.lww.com Both type 1 and type 2 diabetes are characterized by a marked deficit in
beta-cell mass causing insufficient insulin secretion. Beta-cell replacement
strategies may eventually provide a cure for diabetes. Current therapeutic ... Cited by 32 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org K Maedler, DM Schumann, F Schulthess, J … - Diabetes, 2006 - Am Diabetes Assoc Type 2 diabetes is characterized by a deficit in β-cell mass, and its incidence
increases with age. Here, we analyzed β-cell turnover in islets from 2- to 3-
compared with 7- to 8-month-old rats and in human islets from 53 organ ... Cited by 28 - Related articles - BL Direct - All 4 versions
- ►endojournals.org MY Donath, J Storling, LA Berchtold, N … - Endocrine Reviews, 2008 - Endocrine Soc The tale of cytokines and the β-cell is a long story, starting with in vitro
discovery in 1984, evolving via descriptive and phenomenological studies to
detailed mapping of the signalling pathways, gene- and protein expression ... Cited by 20 - Related articles - BL Direct - All 6 versions
S Costes, C Broca, G Bertrand, AD Lajoix, D … - diabetes, 2006 - Am Diabetes Assoc Glucose utilization and oxidation within the pancreatic ß-cells lead to ATP
production and subsequent closure of the ATP-dependent potassium channel,
eliciting the entry of calcium through the opening of L-type ... Cited by 21 - Related articles - BL Direct - All 4 versions
