S Bonner-Weir, GC Weir - Nature biotechnology, 2005 - nature.com Two major initiatives are under way to correct the -cell deficit of diabetes:
one would generate -cells ex vivo that are suitable for transplantation, and the
second would stimulate regeneration of -cells in the pancreas. Studies of ... Cited by 172 - Related articles - All 3 versions
- ►bloodjournal.org V Sordi, ML Malosio, F Marchesi, A Mercalli, R … - Blood, 2005 - Am Soc Hematology Bone marrow–derived mesenchymal stem cells (BM-MSCs) are stromal cells with
the ability to proliferate and differentiate into many tissues. Although they
represent powerful tools for several therapeutic settings, mechanisms ... Cited by 140 - Related articles - BL Direct - All 4 versions
- ►pnas.org RH Lee, MJ Seo, RL Reger, JL Spees, AA … - Proceedings of the National Academy of Sciences, 2006 - National Acad Sciences We tested the hypothesis that multipotent stromal cells from human bone marrow
(hMSCs) can provide a potential therapy for human diabetes mellitus. Severe but
nonlethal hyperglycemia was produced in NOD/scid mice with daily low doses ... Cited by 105 - Related articles - BL Direct - All 14 versions
K Timper, D Seboek, M Eberhardt, P Linscheid, … - Biochemical and biophysical research communications, 2006 - Elsevier Mesenchymal stem cells (MSC) from mouse bone marrow were shown to adopt a
pancreatic endocrine phenotype in vitro and to reverse diabetes in an animal
model. MSC from human bone marrow and adipose tissue represent very similar ... Cited by 99 - Related articles - All 5 versions
- ►diabetesjournals.org LZ Cao, DQ Tang, ME Horb, SW Li, LJ Yang - Diabetes, 2004 - Am Diabetes Assoc Pdx1 has been shown to convert hepatocytes into both exocrine and endocrine
pancreatic cells in mice, but it fails to selectively convert hepatocytes into
pure insulin-producing cells (IPCs). The molecular mechanisms underlying ... Cited by 65 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org H Kaneto, Y Nakatani, T Miyatsuka, T … - Diabetes, 2005 - Am Diabetes Assoc Diabetes is the most prevalent and serious metabolic disease, and the number of
diabetic patients worldwide is increasing. The reduction of insulin biosynthesis
in pancreatic β-cells is closely associated with the onset and progression ... Cited by 51 - Related articles - All 6 versions
H Kaneto, T Matsuoka, Y Nakatani, D … - Journal of Molecular Medicine, 2005 - Springer Page 1. J Mol Med (2005) 83: 429–439 DOI 10.1007/s00109-005-0640-x REVIEW Hideaki
Kaneto . Taka-aki Matsuoka . Yoshihisa Nakatani . Dan Kawamori . ... Cited by 46 - Related articles - All 3 versions
- ►shouxi.net J Taneera, A Rosengren, E Renstrom, JM … - Diabetes, 2006 - Am Diabetes Assoc Recent studies in normal mice have suggested that transplanted bone marrow cells
can transdifferentiate into pancreatic β-cells at relatively high efficiency.
Herein, adopting the same and alternative approaches to deliver and fate ... Cited by 47 - Related articles - BL Direct - All 5 versions
M Banerjee, A Kumar, RR Bhonde - Biochemical and Biophysical Research …, 2005 - Elsevier Therapeutic utility of bone marrow transplantation in diabetic patients to
overcome deficient β-cell population is an attractive proposal. However, the
status of bone marrow stem cells (BMSCs) under hyperglycemia is not known. ... Cited by 43 - Related articles - All 5 versions
- ►alphamedpress.org O Karnieli, Y Izhar-Prato, S Bulvik, S Efrat - Stem Cells, 2007 - AlphaMed Press We have recently shown that stable expression of pancreatic duodenal homeobox 1
(PDX1), a transcription factor that plays key roles in pancreas development and
β-cell gene expression, in cultured human fetal liver cells activates a ... Cited by 44 - Related articles - BL Direct - All 6 versions
