- ►nih.gov M Prentki, CJ Nolan - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig The major focus of this Review is on the mechanisms of islet β cell failure in the pathogenesis
of obesity-associated type 2 diabetes (T2D). As this demise occurs within the context of β cell
compensation for insulin resistance, consideration is also given to the mechanisms ... Cited by 199 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org CJ Nolan, MSR Madiraju, V Delghingaro-Augusto, ML … - Diabetes, 2006 - Am Diabetes Assoc Fatty acids (FAs) and other lipid molecules are important for many cellular functions, including
vesicle exocytosis. For the pancreatic β-cell, while the presence of some FAs is essential for
glucose-stimulated insulin secretion, FAs have enormous capacity to amplify glucose- ... Cited by 55 - Related articles - BL Direct - All 5 versions
CJ Nolan, JL Leahy, V Delghingaro-Augusto, J Moibi, K … - Diabetologia, 2006 - Springer Page 1. ARTICLE Beta cell compensation for insulin resistance in Zucker fatty rats:
increased lipolysis and fatty acid signalling CJ Nolan & JL Leahy & V. Delghingaro-
Augusto & J. Moibi & K. Soni & M.-L. Peyot & M. Fortier & C. Guay & ... Cited by 44 - Related articles - BL Direct - All 3 versions
C Guay, SR Madiraju, A Aumais, E Joly, M Prentki - Journal of Biological …, 2007 - ASBMB In pancreatic β-cells, metabolic coupling factors generated during glucose metabolism and pyruvate
cycling through anaplerosis/cataplerosis processes contribute to the regulation of insulin
secretion. Pyruvate/citrate cycling across the mitochondrial membrane leads to the ... Cited by 25 - Related articles - All 4 versions
- ►diabetesjournals.org EP Kwan, L Xie, L Sheu, CJ Nolan, M Prentki, A Betz, N … - Diabetes, 2006 - Am Diabetes Assoc Munc13-1 is a diacylglycerol (DAG) receptor that is essential for synaptic vesicle priming. We
recently showed that Munc13-1 is expressed in rodent and human islet β-cells and that its levels
are reduced in islets of type 2 diabetic humans and rat models, suggesting that Munc13-1 ... Cited by 21 - Related articles - All 5 versions
R Zechner, PC Kienesberger, G Haemmerle, R … - The Journal of Lipid …, 2009 - ASBMB Fatty acids (FAs) are essential components of all lipid classes and pivotal substrates for energy
production in all vertebrates. Additionally, they act directly or indirectly as signaling molecules
and, when bonded to amino acid side chains of peptides, anchor proteins in biological ... Cited by 19 - Related articles - All 6 versions
- ►aspetjournals.org TH Claus, DB Lowe, Y Liang, AI Salhanick, CK … - Journal of Pharmacology …, 2005 - ASPET Elevation of plasma free fatty acids has been linked with insulin resistance and diabetes. Inhibition
of lipolysis may provide a mechanism to decrease plasma fatty acids, thereby improving insulin
sensitivity. Hormone-sensitive lipase (HSL) is a critical enzyme involved in the hormonally ... Cited by 16 - Related articles - BL Direct - All 5 versions
FB Kraemer, WJ Shen - Nutrition & Metabolism, 2006 - biomedcentral.com Abstract All treatments for obesity, including dietary restriction of carbohydrates, have a goal
of reducing the storage of fat in adipocytes. The chief enzyme responsible for the mobilization
of FFA from adipose tissue, ie, lipolysis, is thought to be hormone-sensitive lipase (HSL). ... Cited by 17 - Related articles - View as HTML - All 10 versions
JWE Jocken, EE Blaak - Physiology & Behavior, 2008 - Elsevier Increased fat storage in adipose and non-adipose tissue (eg skeletal muscle) characterizes the
obese insulin resistant state. Disturbances in pathways of lipolysis may play a role in the development
and maintenance of these increased fat stores. A reduced catecholamine-induced ... Cited by 15 - Related articles - All 2 versions
- ►endojournals.org M Prentki, SR Madiraju - Endocrine reviews, 2008 - Endocrine Soc GL/FFA cycle is referred to as a "futile" cycle because it involves continuous formation and hydrolysis
of GL with the release of heat, at the expense of ATP. However, we present evidence underscoring
the "vital" cellular signaling roles of the GL/FFA cycle for many biological processes. ... Cited by 14 - Related articles - All 5 versions
