- ►endojournals.org SK Srivastava, KV Ramana, A Bhatnagar - Endocrine reviews, 2005 - Endocrine Soc Aldose reductase (AR) is widely expressed aldehyde-metabolizing enzyme. The reduction of
glucose by the AR-catalyzed polyol pathway has been linked to the development of secondary
diabetic complications. Although treatment with AR inhibitors has been shown to prevent ... Cited by 97 - Related articles - All 6 versions
IG Obrosova, P Pacher, C Szabó, Z Zsengeller, H … - Diabetes, 2005 - Am Diabetes Assoc This study evaluated the effects of aldose reductase inhibition on diabetes-induced
oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation. In animal
experiments, control and streptozotocin-induced diabetic rats were treated with or without ... Cited by 73 - Related articles - All 8 versions
DM Niedowicz, DL Daleke - Cell biochemistry and biophysics, 2005 - Springer The morbidity and mortality associated with diabetes is the result of the myriad complications
related to the disease. One of the most explored hypotheses to explain the onset of complications
is a hyperglycemia-induced increase in oxidative stress. Reactive oxygen species (ROS) ... Cited by 53 - Related articles - BL Direct - All 6 versions
DA Allen, MM Yaqoob, SM Harwood - The Journal of Nutritional Biochemistry, 2005 - Elsevier Cellular responses to high glucose are numerous and varied but ultimately result in functional
changes and, often, cell death. High glucose induces oxidative and nitrosative stress in many
cell types causing the generation of species such as superoxide, nitric oxide and ... Cited by 40 - Related articles - All 9 versions
- ►nih.gov VR Drel, P Pacher, MJ Stevens, IG Obrosova - Free Radical Biology and …, 2006 - Elsevier Both increased aldose reductase (AR) activity and oxidative/nitrosative stress have been implicated
in the pathogenesis of diabetic nephropathy, but the relation between the two factors remains
a subject of debate. This study evaluated the effects of AR inhibition on nitrosative stress ... Cited by 34 - Related articles - All 6 versions
- ►diabetesjournals.org VR Drel, N Mashtalir, O Ilnytska, J Shin, F Li, VV … - Diabetes, 2006 - Am Diabetes Assoc Whereas functional, metabolic, neurotrophic, and morphological abnormalities of peripheral
diabetic neuropathy (PDN) have been extensively explored in streptozotocin-induced diabetic
rats and mice (models of type 1 diabetes), insufficient information is available on ... Cited by 31 - Related articles - BL Direct - All 7 versions
E Ho, KSL Lam, YS Chen, JCW Yip, M Arvindakshan, … - Diabetes, 2006 - Am Diabetes Assoc The exaggerated flux through polyol pathway during diabetes is thought to be a major cause
of lesions in the peripheral nerves. Here, we used aldose reductase (AR)-deficient (AR −/− )
and AR inhibitor (ARI)-treated mice to further understand the in vivo role of polyol ... Cited by 31 - Related articles - BL Direct - All 7 versions
- ►cjb.net EK Wittmack, AM Rush, A Hudmon, SG Waxman, … - Journal of …, 2005 - neuro.cjb.net Na v 1.6 is the major sodium channel isoform at nodes of Ranvier in myelinated axons and,
additionally, is distributed along unmyelinated C-fibers of sensory neurons. Thus, modulation
of the sodium current produced by Na v 1.6 might significantly impact axonal conduction. ... Cited by 27 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org F Li, VR Drel, C Szabó, MJ Stevens, IG Obrosova - Diabetes, 2005 - Am Diabetes Assoc Poly(ADP-ribose) polymerase (PARP) inhibition has recently been identified as a novel approach
to treatment of experimental peripheral diabetic neuropathy (PDN). However, long-term inhibition
of PARP, an enzyme involved in DNA repair, can potentially result in premature aging, ... Cited by 25 - Related articles - All 5 versions
IG Obrosova, UA Julius - Current Vascular Pharmacology, 2005 - ingentaconnect.com Abstract: Chronic complications of diabetes mellitus ea diabetic nephropathy, neuropathy and
retinopathy develop in at least 30-50% of patients with both Type 1 (insulin-dependent) and Type
2 (non-insulin-dependent) diabetes, and are the major cause of increased morbidity and ... Cited by 22 - Related articles - All 2 versions
