- ►nih.gov MA Permutt, J Wasson, N Cox - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Conventional genetic analysis focuses on the genes that account for specific
phenotypes, while traditional epidemiology is more concerned with the
environmental causes and risk factors related to traits. Genetic ... Cited by 90 - Related articles - All 9 versions
MA Cornier, D Dabelea, TL Hernandez, RC … - Endocrine Reviews, 2008 - Endocrine Soc The "metabolic syndrome" (MetS) is a clustering of components that reflect
overnutrition, sedentary lifestyles, and resultant excess adiposity. The MetS
includes the clustering of abdominal obesity, insulin resistance, ... Cited by 41 - Related articles - All 5 versions
BS Sutton, S Weinert, CD Langefeld, AH … - Human genetics, 2005 - Springer Abstract Adiponectin, coded for by the APM1 gene, is a novel adipocyte-derived
hormone implicated in energy homeostasis and obesity. Several genetic studies
have observed evidence of association between APM1 gene polymorphisms and ... Cited by 28 - Related articles - All 3 versions
- ►endojournals.org SM Clee, AD Attie - Endocrine reviews, 2007 - Endocrine Soc Inbred mouse strains provide genetic diversity comparable to that of the human
population. Like humans, mice have a wide range of diabetes-related phenotypes.
The inbred mouse strains differ in the response of their critical ... Cited by 28 - Related articles - BL Direct - All 4 versions
- ►critcaremed.com JM Saland - Current opinion in pediatrics, 2007 - journals.lww.com Purpose of review Provides an update on the metabolic syndrome in childhood.
Recent findings The metabolic syndrome is increasingly recognized among
children. It is nearly exclusively encountered in overweight and obese ... Cited by 26 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org SS Rich, DW Bowden, SM Haffner, JM Norris, … - Diabetes, 2005 - Am Diabetes Assoc Plasma insulin and glucose concentrations are important quantitative phenotypes
related to diabetes and the metabolic syndrome. Reports purporting to identify
quantitative trait loci (QTLs) that contribute to the variation in fasting ... Cited by 18 - Related articles - All 5 versions
- ►endojournals.org H Oberkofler, K Klein, TK Felder, F Krempler, … - Endocrinology, 2006 - Endocrine Soc A role of uncoupling protein 2 (UCP2) as negative modulator of insulin secretion
has been suggested, but the transcriptional pathways regulating ß-cell UCP2
gene expression have been established in rodents only. We show here that ... Cited by 15 - Related articles - BL Direct - All 3 versions
- ►shouxi.net ND Palmer, CD Langefeld, JK Campbell, AH … - Diabetes, 2006 - Am Diabetes Assoc Glucose homeostasis, a defining characteristic of physiological glucose
metabolism, is the result of complex feedback relationships with both genetic
and environmental determinants that influence insulin sensitivity and ... Cited by 14 - Related articles - BL Direct - All 5 versions
CJ Gallagher, CD Langefeld, CJ Gordon, JK … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE— We previously detected an association between a region of the
estrogen receptor-α (ESR1) gene and type 2 diabetes in an African-American
case-control study; thus, we investigated this region for associations with ... Cited by 14 - Related articles - BL Direct - All 4 versions
- ►shouxi.net EH Leiter, CH Lee - Diabetes, 2005 - Am Diabetes Assoc In humans, both type 1 and type 2 diabetes exemplify genetically heterogeneous
complex diseases in which epigenetic factors contribute to underlying genetic
susceptibility. Extended human pedigrees often show inheritance of both ... Cited by 10 - Related articles - BL Direct - All 6 versions
