D Smyth, JD Cooper, JE Collins, JM Heward, JA … - Diabetes, 2004 - Am Diabetes Assoc In the genetic analysis of common, multifactorial diseases, such as type 1 diabetes, true positive
irrefutable linkage and association results have been rare to date. Recently, it has been reported
that a single nucleotide polymorphism (SNP), 1858C>T, in the gene PTPN22, encoding ... Cited by 244 - Related articles - BL Direct - All 5 versions
DJ Smyth, JD Cooper, R Bailey, S Field, O Burren, LJ … - Nature genetics, 2006 - nature.com 2 Clinic of Diabetes, Institute of Diabetes, Nutrition and Metabolic Diseases 'N.Paulescu', Bucharest
79811, Romania. ... 3 Department of Paediatrics, University of Cambridge, Addenbrooke's
Hospital, Cambridge CB2 2XY, UK. ... 4 Department of Medical Genetics, Queen's ... Cited by 190 - Related articles - BL Direct - All 6 versions
- ►nih.gov A Vella, JD Cooper, CE Lowe, N Walker, S Nutland, … - The American Journal of …, 2005 - Elsevier Despite hundreds of association studies, few have been consistently replicated (Dahlman et
al. 2002; Hirschhorn et al. 2003; Ioannidis et al. 2003; Lohmueller et al. 2003). In type 1 diabetes
(T1D [MIM 222100]), only four loci have been identified and successfully replicated: the ... Cited by 137 - Related articles - All 6 versions
JC Knight - Journal of molecular medicine, 2005 - Springer Abstract There is growing evidence that genetic variation plays an important role in the determination
of individual susceptibility to complex disease traits. In contrast to coding sequence
polymorphisms, where the consequences of non-synonymous variation may be resolved ... Cited by 101 - Related articles - All 4 versions
- ►nih.gov MA Permutt, J Wasson, N Cox - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Conventional genetic analysis focuses on the genes that account for specific phenotypes, while
traditional epidemiology is more concerned with the environmental causes and risk factors related
to traits. Genetic epidemiology is an alliance of the 2 fields that focuses on both genetics, ... Cited by 91 - Related articles - All 9 versions
W Zheng, JX She - Diabetes, 2005 - Am Diabetes Assoc The lymphoid-specific phosphatase (LYP) encoded by PTPN22 is involved in preventing spontaneous
T-cell activation by dephosphorylating and inactivating T-cell receptor-associated Csk
kinase. We have genotyped 396 type 1 diabetic patients and 1,178 control subjects of ... Cited by 63 - Related articles - All 5 versions
- ►cell.com SHS Pearce, TR Merriman - Trends in molecular medicine, 2006 - Elsevier The past few years have seen the identification of PTPN22 and the confirmation of CTLA-4 as
common autoimmune disease genes. Together with MHC and INS, these developments have
increased the collection of confirmed susceptibility loci for autoimmunity. In this article, the ... Cited by 46 - Related articles - All 5 versions
- ►oxfordjournals.org MJ Simmonds, SCL Gough - British medical bulletin, 2005 - British Council Educating the immune system to distinguish between self and non-self is critical to ensure that
an immune response is mounted against foreign antigens and not against self. A breakdown
in these mechanisms can lead to the onset of autoimmune disease. Clinical and ... Cited by 43 - Related articles - All 5 versions
- ►harvard.edu [PDF] LS Wicker, J Clark, HI Fraser, VES Garner, A … - Journal of Autoimmunity, 2005 - Elsevier The identification of causative genes for the autoimmune disease type 1 diabetes (T1D) in humans
and candidate genes in the NOD mouse has made significant progress in recent years. In addition
to sharing structural aspects of the MHC class II molecules that confer susceptibility or ... Cited by 42 - Related articles - All 6 versions
JN HIRSCHHORN - Pediatric research, 2005 - journals.lww.com Most common diseases and most quantitative traits that can be measured in human populations
are complex genetic traits. That is, many genetic and nongenetic factors interact to determine
the final phenotype, whether that phenotype is susceptibility to disease, or a quantifiable ... Cited by 40 - Related articles - All 4 versions
