- ►diabetesjournals.org M Cnop, N Welsh, JC Jonas, A Jörns, S Lenzen … - Diabetes, 2005 - Am Diabetes Assoc Type 1 and type 2 diabetes are characterized by progressive β-cell failure.
Apoptosis is probably the main form of β-cell death in both forms of the
disease. It has been suggested that the mechanisms leading to nutrient- and ... Cited by 171 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org TA Buchanan, A Xiang, SL Kjos, R Watanabe - Diabetes Care, 2007 - Am Diabetes Assoc Gestational diabetes mellitus (GDM) is defined as glucose intolerance with onset
or first recognition during pregnancy. As such, GDM is the product of routine
glucose tolerance screening that is currently carried out in otherwise ... Cited by 169 - Related articles - BL Direct - All 17 versions
LE Fridlyand, LH Philipson - Diabetes Obesity and Metabolism, 2006 - interscience.wiley.com The early stages of type 2 diabetes mellitus are characterized by the
development of insulin resistance (IRe) in muscle cells and adipocytes with the
concomitant loss of β-cell compensation. We have extensively reviewed the ... Cited by 45 - Related articles - BL Direct - All 4 versions
CJ Bailey, A Bagdonas, J Rubes, SO McMorn, … - Clinical therapeutics, 2005 - Elsevier A total of 568 patients comprised the safety 1026 population (MET, 280; RSG/MET,
288) and 551 formed the intent-to-treat group (MET, 272; RSG/MET, 279). Baseline
characteristics of the safety population were comparable in the 2 groups; ... Cited by 46 - Related articles - All 4 versions
CG Taylor - Biometals, 2005 - Springer Molecular and cellular studies have demonstrated several roles for zinc (Zn) in
insulin production and the consequent actions of insulin on metabolism. Clinical
and epidemiological studies suggest that reduced Zn status is associated ... Cited by 34 - Related articles - BL Direct - All 4 versions
- ►shouxi.net J Pi, Y Bai, Q Zhang, V Wong, LM Floering, K … - Diabetes, 2007 - Am Diabetes Assoc One of the unique features of β-cells is their relatively low expression of
many antioxidant enzymes. This could render β-cells susceptible to oxidative
damage but may also provide a system that is sensitive to reactive oxygen ... Cited by 35 - Related articles - BL Direct - All 6 versions
- ►jbc.org GA Martens, Y Cai, S Hinke, G Stange, M Van … - Journal of Biological Chemistry, 2005 - ASBMB High rates of glucose metabolism and mitochondrial electron transport have been
associated with increased mitochondrial production of reactive oxygen species
(ROS). This mechanism was also proposed as a possible cause for dysfunction ... Cited by 32 - Related articles - All 6 versions
D Morgan, HR Oliveira-Emilio, D Keane, AE … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis Acute or chronic exposure of beta cells to glucose,
palmitic acid or pro-inflammatory cytokines will result in increased production
of the p47 phox component of the NADPH oxidase and subsequent production of ... Cited by 25 - Related articles - BL Direct - All 4 versions
LE Fridlyand, LH Philipson - ANNALS-NEW YORK ACADEMY OF SCIENCES, 2005 - interscience.wiley.com Abstract: Mammalian cells are continuously subject to insult from reactive
species. Most of the pathogenic mechanisms that have been considered to date
reflect overproduction of reactive oxygen species (ROS) or a peculiar ... Cited by 21 - Related articles - BL Direct - All 5 versions
- ►shouxi.net C Leloup, C Magnan, A Benani, E Bonnet, T … - Diabetes, 2006 - Am Diabetes Assoc The physiological signaling mechanisms that link glucose sensing to the
electrical activity in metabolism-regulating hypothalamus are still
controversial. Although ATP production was considered the main metabolic ... Cited by 21 - Related articles - BL Direct - All 5 versions
