- ►nih.gov FM Ashcroft - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig ATP-sensitive potassium (K ATP ) channels, so named because they are inhibited by intracellular
ATP , play key physiological roles in many tissues. In pancreatic β cells, these channels regulate
glucose-dependent insulin secretion and serve as the target for sulfonylurea drugs used ... Cited by 142 - Related articles - BL Direct - All 14 versions
C Broberger - Journal of internal medicine, 2005 - nutrinfo.com In the clinic, obesity and anorexia constitute prevalent problems whose manifestations are encountered
in virtually every field of medicine. However, as the command centre for regulating food intake
and energy metabolism is located in the brain, the basic neuroscientist sees in the same ... Cited by 97 - Related articles - View as HTML - BL Direct - All 6 versions
- ►poldracklab.org [PDF] BW Balleine - Physiology & behavior, 2005 - Elsevier Recent studies suggest that there are multiple 'reward' or 'reward-like' systems that control food
seeking; evidence points to two distinct learning processes and four modulatory processes that
contribute to the performance of food-related instrumental actions. The learning ... Cited by 85 - Related articles - All 9 versions
D Porte, DG Baskin, MW Schwartz - Diabetes, 2005 - Am Diabetes Assoc Insulin and its signaling systems are implicated in both central and peripheral mechanisms governing
the ingestion, distribution, metabolism, and storage of nutrients in organisms ranging from worms
to humans. Input from the environment regarding the availability and type of nutrients is ... Cited by 77 - Related articles - All 8 versions
- ►nih.gov L Plum, BF Belgardt, JC Brüning - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig Insulin has pleiotropic biological effects in virtually all tissues. However, the relevance of insulin
signaling in peripheral tissues has been studied far more extensively than its role in the
brain. An evolving body of evidence indicates that in the brain, insulin is involved in ... Cited by 76 - Related articles - BL Direct - All 11 versions
- ►nih.gov M Claret, MA Smith, RL Batterham, C … - Journal of Clinical …, 2007 - Am Soc Clin Investig 1 Centre for Diabetes and Endocrinology, Rayne Institute, University College London,
London, United Kingdom. 2 Neurosciences Institute, Pathology and Neuroscience Division, Ninewells
Hospital and Medical School, University of Dundee, Dundee, United Kingdom. 3 Cellular ... Cited by 64 - Related articles - BL Direct - All 15 versions
- ►diabetesjournals.org Z Song, VH Routh - Diabetes, 2005 - Am Diabetes Assoc Glucose directly alters the action potential frequency of glucosensing neurons in the ventromedial
hypothalamic nucleus (VMN). Glucose-excited neurons increase, and glucose-inhibited neurons
decrease, their action potential frequency as glucose increases from 0.1 to 2.5 mmol/l. ... Cited by 61 - Related articles - All 7 versions
- ►oxfordjournals.org L Visser, CJ Zuurbier, FJ Hoek, BC … - British Journal of …, 2005 - British Jrnl Anaesthesia Methods. Data obtained in 21 non-diabetic patients with normal left ventricular function scheduled
for elective coronary artery surgery, who were randomly allocated to a control or GIK group, were
analysed. In GIK patients, regular insulin was infused at a fixed rate of 0.1 IU kg –1 h –1 . ... Cited by 56 - Related articles - BL Direct - All 12 versions
- ►diabetesjournals.org L Kang, AA Dunn-Meynell, VH Routh, LD Gaspers, Y … - Diabetes, 2006 - Am Diabetes Assoc To test the hypothesis that glucokinase is a critical regulator of neuronal glucosensing, glucokinase
activity was increased, using a glucokinase activator drug, or decreased, using RNA interference
combined with calcium imaging in freshly dissociated ventromedial hypothalamic nucleus ... Cited by 49 - Related articles - BL Direct - All 7 versions
S Ramamurthy, GV Ronnett - The Journal of physiology, 2006 - Physiological Soc The 5′-adenosine monophosphate-activated protein kinase (AMPK) is a metabolic and stress
sensor that has been functionally conserved throughout eukaryotic evolution. Activation of the
AMPK system by various physiological or pathological stimuli that deplete cellular energy ... Cited by 41 - Related articles - BL Direct - All 9 versions
