- ►rupress.org W Jiang, MS Anderson, R Bronson, D Mathis, … - Journal of Experimental …, 2005 - jem.rupress.org Loss of function mutations in the autoimmune regulator (Aire) gene in autoimmune
polyendocrinopathy-candidiasis-ectodermal dystrophy patients and mutant mice lead to autoimmune
manifestations that segregate as a monogenic trait, but with wide variation in the ... Cited by 59 - Related articles - BL Direct - All 10 versions
- ►harvard.edu [PDF] LS Wicker, J Clark, HI Fraser, VES Garner, A … - Journal of Autoimmunity, 2005 - Elsevier The identification of causative genes for the autoimmune disease type 1 diabetes (T1D) in humans
and candidate genes in the NOD mouse has made significant progress in recent years. In addition
to sharing structural aspects of the MHC class II molecules that confer susceptibility or ... Cited by 42 - Related articles - All 6 versions
BC Beaudette-Zlatanova, B Whalen, D … - American Journal of …, 2006 - interscience.wiley.com Costimulatory signals regulate T-cell activation. To investigate the role of costimulation in autoimmunity
and transplantation, we studied the BB rat model of type 1 diabetes. Diabetes-prone BB
(BBDP) rats spontaneously develop disease when 55–120 days of age. We observed that ... Cited by 8 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org EJ Gordon, LS Wicker, LB Peterson, DV Serreze, TG … - Diabetes, 2005 - Am Diabetes Assoc Costimulation blockade induces prolonged rat islet and skin xenograft survival in C57BL/6
mice. Nonobese diabetic (NOD) mice, which are used to model human autoimmune
diabetes, are resistant to costimulation blockade-induced allograft tolerance. We tested ... Cited by 6 - Related articles - All 7 versions
DB Rainbow, L Esposito, SK Howlett, KM … - Biochemical Society …, 2008 - pubmedcentral.nih.gov The MHC region remains the major genetic determinant causing T1D in humans and NOD mice
[1, 2] and the identification of non-MHC genes contributing T1D susceptibility has made significant
progress. Of particular note, in 2007 it was demonstrated unequivocally that ... Cited by 6 - Related articles - BL Direct - All 9 versions
CA Dendrou, V Plagnol, E Fung, JHM Yang, K Downes, … - Nature Genetics, 2009 - ugr.es Genome-wide association studies (GWAS) have identified over 300 regions associated with
more than 70 common diseases1. However, identifying causal genes within an associated region
remains a major challenge1,2. One approach to resolving causal genes is through the ... Cited by 6 - Related articles - View as HTML - All 4 versions
CA Dendrou, LS Wicker - Journal of Clinical Immunology, 2008 - Springer Abstract Although the interleukin-2 (IL-2)/IL-2R signal- ing pathway has been the focus of numerous
studies, certain aspects of its molecular regulation are not well characterized, especially in
non-T cells, and a more complete understanding of the pathway is necessary to discern ... Cited by 3 - Related articles - All 2 versions
DA Chistiakov, NV Voronova, PA Chistiakov - Immunology Letters, 2008 - Elsevier Interleukin-2 (IL-2) plays an established role in T-cell regulation through binding to the high-affinity
IL-2 receptor (IL-2R). The α-chain encoded by the IL2RA (CD25) gene is a substantial component
of the high-affinity receptor molecule highly expressed by activated T lymphocytes. ... Cited by 2 - Related articles - All 4 versions
Z Xiang, LL Ma, S Manicassamy, BB Ganesh, P … - Transplantation, 2008 - journals.lww.com Transplantation. Wolters Kluwer Health Logo. All Issues. ... Cited by 2 - Related articles - BL Direct - All 3 versions
