PA Silveira, ST Grey - Trends in Endocrinology & Metabolism, 2006 - Elsevier It has long been established that type 1 diabetes (T1D) is a T cell-mediated
autoimmune disease, with CD4 + and CD8 + T cells being largely responsible for
the destruction of β cells within the pancreatic islets of Langerhans. ... Cited by 24 - Related articles - All 6 versions
- ►jimmunol.org S Hussain, TL Delovitch - The Journal of Immunology, 2005 - Am Assoc Immnol Little is known about the pathogenic role of B cell dysfunction in T
cell-mediated autoimmune disease. We previously reported that B cell
hyper-responsiveness, resistance to apoptosis, and accumulation in islets ... Cited by 21 - Related articles - All 5 versions
- ►jimmunol.org PKA Mongini, JK Inman, H Han, RJ Fattah, SB … - The Journal of Immunology, 2006 - Am Assoc Immnol Of relevance to both protective and pathogenic responses to Ag is the recent
finding that soluble molecules of the innate immune system, ie, IL-4, B
cell-activation factor of the TNF family (BAFF), and C3, exhibit ... Cited by 15 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org PKA Mongini, JK Inman, H Han, SL Kalled, RJ … - The Journal of Immunology, 2005 - Am Assoc Immnol Foci of autoantigen-specific B lymphocytes in nonlymphoid tissues have been
associated with development of autoimmune disease. To better understand the
genesis of such ectopic lymphoid tissue, this study investigated whether ... Cited by 10 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org S Hussain, TL Delovitch - The Journal of Immunology, 2007 - Am Assoc Immnol Although B cells play a pathogenic role in the initiation of type 1 diabetes
(T1D) in NOD mice, it is not known whether activated B cells can maintain
tolerance and transfer protection from T1D. In this study, we demonstrate ... Cited by 8 - Related articles - All 4 versions
FS Wong, L Wen - The Review of Diabetic Studies, 2005 - pubmedcentral.nih.gov Autoantibodies have been used as good markers for the prediction of future
development of type 1 diabetes mellitus (T1DM), but are not thought to be
pathogenic in this disease. The role of B cells that produce autoantibodies ... Cited by 8 - Related articles - All 6 versions
- ►jimmunol.org PA Silveira, HD Chapman, J Stolp, E Johnson … - The Journal of Immunology, 2006 - Am Assoc Immnol Autoreactive T cells clearly mediate the pancreatic β cell destruction causing
type 1 diabetes (T1D). However, studies in NOD mice indicate that B cells also
contribute to pathogenesis because their ablation by introduction of an ... Cited by 7 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org AM Marleau, KL Summers, B Singh - The Journal of Immunology, 2008 - Am Assoc Immnol Despite the pivotal role of dendritic cells (DC) in shaping immunity, little is
known about their functionality in type 1 diabetes. Moreover, due to the paucity
of DC in vivo, functional studies have relied largely upon in ... Cited by 4 - Related articles - All 2 versions
- ►jimmunol.org MC Puertas, J Carrillo, X Pastor, RM Ampudia, … - The Journal of Immunology, 2007 - Am Assoc Immnol Most of our knowledge of the antigenic repertoire of autoreactive B lymphocytes
in type 1 diabetes (T1D) comes from studies on the antigenic specificity of both
circulating islet-reactive autoantibodies and peripheral B lymphocyte ... Cited by 2 - Related articles - All 6 versions
J Wu, J Marler, NI Lenchik, IC Gerling - Immunology letters, 2006 - Elsevier Use of allele-specific monoclonal antibodies revealed that the previously
uncharacterized NON strain expresses either the a or d allele, whereas NOD and
AKR mice were confirmed to express the rare c allele. Flow cytometric ... Cited by 2 - Related articles - All 5 versions
