- ►diabetesjournals.org G Wolf, S Chen, FN Ziyadeh - Diabetes, 2005 - Am Diabetes Assoc Nephropathy is a major complication of diabetes. Alterations of mesangial cells have traditionally
been the focus of research in deciphering molecular mechanisms of diabetic nephropathy. Injury
of podocytes, if recognized at all, has been considered a late consequence caused by ... Cited by 188 - Related articles - All 9 versions
Y Ohshiro, RC Ma, Y Yasuda, J Hiraoka-Yamamoto, … - Diabetes, 2006 - Am Diabetes Assoc Diabetes induces the activation of several protein kinase C (PKC) isoforms in the renal
glomeruli. We used PKC-β −/− mice to examine the action of PKC-β isoforms in diabetes-induced
oxidative stress and renal injury at 8 and 24 weeks of disease. Diabetes increased PKC ... Cited by 38 - Related articles - BL Direct - All 6 versions
MP Cohen, S Chen, FN Ziyadeh, E Shea, EA Hud, GT … - Kidney international, 2005 - nature.com Albumin modified by Amadori-glucose adducts has been linked to the development of diabetic
nephropathy through its ability, independent of hyperglycemia, to activate protein kinase C-
(PKC- ), up-regulate the transforming growth factor- (TGF- ) system, and stimulate ... Cited by 35 - Related articles - BL Direct - All 4 versions
KG Ewens, RA George, K Sharma, FN Ziyadeh, RS … - Diabetes, 2005 - Am Diabetes Assoc Several lines of evidence, including familial aggregation, suggest that allelic variation contributes
to risk of diabetic nephropathy. To assess the evidence for specific susceptibility genes, we used
the transmission/disequilibrium test (TDT) to analyze 115 candidate genes for linkage ... Cited by 34 - Related articles - BL Direct - All 5 versions
J Menne, M Meier, JK Park, M Boehne, T Kirsch, C … - Kidney international, 2006 - nature.com Albuminuria in diabetic nephropathy is due to endothelial dysfunction, a loss of negative charges
in the basement membrane, and changes a of the slit-membrane diaphragm composition. We
have recently shown that protein kinase C alpha (PKC )-deficient mice are protected ... Cited by 22 - Related articles - BL Direct - All 6 versions
K Yamauchi, Y Takano, A Kasai, K Hayakawa, N … - Kidney international, 2006 - nature.com Downregulation of nephrin in podocytes leads to development of proteinuria in human and experimental
kidney diseases. However, little is understood about pathophysiologic substances that regulate
nephrin expression. In this report, we established conditionally immortalized reporter ... Cited by 21 - Related articles - BL Direct - All 4 versions
- ►oxfordjournals.org EY Lee, CH Chung, JH Kim, HJ Joung, SY … - Nephrology Dialysis …, 2006 - ERA-EDTA Results. Intracellular ROS generation was significantly higher in high glucose than in control
conditions in cultured podocytes. High ambient glucose also increased VEGF mRNA and protein
expression. The high-glucose-induced increases in ROS and VEGF mRNA and protein ... Cited by 20 - Related articles - All 8 versions
Y Zhu, HK Usui, K Sharma - Seminars in nephrology, 2007 - pubmedcentral.nih.gov The recognition of the drivers of matrix accumulation as a therapeutic target for diabetic nephropathy
is accepted by the Nephrology and pharmaceutical community. Interventions focused around
Transforming Growth Factor–beta (TGF–β) will likely be an important area of clinical ... Cited by 21 - Related articles - All 9 versions
M Meier, JK Park, D Overheu, T Kirsch, C Lindschau, F … - Diabetes, 2007 - Am Diabetes Assoc The protein kinase C (PKC)-β isoform has been implicated to play a pivotal role in the development
of diabetic kidney disease. We tested this hypothesis by inducing diabetic nephropathy in
PKC-β–deficient (PKC-β −/− ) mice. We studied nondiabetic and streptozotocin-induced ... Cited by 17 - Related articles - BL Direct - All 6 versions
