- ►nih.gov FM Ashcroft - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig ATP-sensitive potassium (K ATP ) channels, so named because they are inhibited by intracellular
ATP , play key physiological roles in many tissues. In pancreatic β cells, these channels regulate
glucose-dependent insulin secretion and serve as the target for sulfonylurea drugs used ... Cited by 142 - Related articles - BL Direct - All 14 versions
- ►diabetesjournals.org FM Matschinsky, MA Magnuson, D Zelent, TL Jetton, N … - Diabetes, 2006 - Am Diabetes Assoc The glucose-phosphorylating enzyme glucokinase has structural, kinetic, and molecular genetic
features that are ideal for its primary role as glucose sensor in a network of neuro/endocrine
sentinel cells that maintain glucose homeostasis in many vertebrates including humans. ... Cited by 75 - Related articles - BL Direct - All 10 versions
ME Patti, G McMahon, EC Mun, A Bitton, JJ Holst, J … - Diabetologia, 2005 - Springer Page 1. Diabetologia (2005) 48: 2236–2240 DOI 10.1007/s00125-005-1933-x SHORT
COMMUNICATION ME Patti . G. McMahon . EC Mun . A. Bitton . JJ Holst . J. Goldsmith . DW
Hanto . M. Callery . R. Arky . V. Nose . S. Bonner-Weir . AB Goldfine ... Cited by 71 - Related articles - BL Direct - All 3 versions
AL Gloyn, S Odili, D Zelent, C Buettger, HAJ … - Journal of Biological …, 2005 - ASBMB Glucokinase (GCK) serves as the pancreatic glucose sensor. Heterozygous inactivating GCK
mutations cause hyperglycemia, whereas activating mutations cause hypoglycemia. We studied
the GCK V62M mutation identified in two families and co-segregating with hyperglycemia ... Cited by 31 - Related articles - All 7 versions
- ►kuleuven.be [PDF] N Bouatia-Naji, G Rocheleau, L Van Lommel, K … - Science, 2008 - sciencemag.org Page 1. DOI: 10.1126/science.1156849 , 1085 (2008); 320 Science et al. Nabila
Bouatia-Naji, Associated with Fasting Plasma Glucose Levels Gene Is G6PC2 A
Polymorphism Within the www.sciencemag.org (this information ... Cited by 30 - Related articles - BL Direct - All 11 versions
DD De León, CA Stanley - Nature Clinical Practice Endocrinology & …, 2007 - nature.com Diva D De León is an Assistant Professor of Pediatrics at the University of Pennsylvania,
Philadelphia, PA, USA, and an Attending Physician in the Division of Endocrinology, The Children's
Hospital of Philadelphia. Her research interest is on disorders of carbohydrate ... Cited by 28 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org JV Sagen, S Odili, L Bjørkhaug, D Zelent, C Buettger, J … - Diabetes, 2006 - Am Diabetes Assoc Glucokinase functions as a glucose sensor in pancreatic β-cells and regulates hepatic glucose
metabolism. A total of 83 probands were referred for a diagnostic screening of mutations in the
glucokinase (GCK) gene. We found 11 different mutations (V62A, G72R, L146R, A208T, ... Cited by 20 - Related articles - BL Direct - All 5 versions
- ►unc.edu [PDF] VV Heredia, J Thomson, D Nettleton, S Sun - Biochemistry, 2006 - pubs.acs.org The transient kinetics of glucose binding to glucokinase (GK) was studied using stopped-flow
fluorescence spectrophotometry to investigate the underlying mechanism of positive cooperativity
of monomeric GK with glucose. Glucose binding to GK was shown to display biphasic ... Cited by 19 - Related articles - All 5 versions
GJ Coope, AM Atkinson, C Allott, D … - British journal of …, 2006 - pubmedcentral.nih.gov Four GKAs (at 1 to 30 mg kg −1 ), with different in vitro enzyme potencies, dose-dependently
improved oral glucose tolerance in HFFZ rats (10–40% decrease glucose area under the curve
(AUC) from vehicle control). The extent of glucose lowering, or the pharmacodynamic ... Cited by 18 - Related articles - BL Direct - All 4 versions
- ►bmj.com JR Porter, TG Barrett - British Medical Journal, 2005 - jmg.bmj.com Type 2 diabetes mellitus is caused by a combination of insulin resistance and ß cell failure. The
polygenic nature of type 2 diabetes has made it difficult to study. Although many candidate genes
for this condition have been suggested, in most cases association studies have been ... Cited by 15 - Related articles - BL Direct - All 10 versions
