H Yki-Jarvinen - New England Journal of Medicine, 2004 - content.nejm.org Insulin resistance both precedes and predicts type 2 diabetes mellitus. 1 Although exercise and
weight loss ameliorate insulin resistance and may in some cases prevent or delay onset of the
disease, 2 therapy that combats insulin resistance in those who fail to change their ... Cited by 847 - Related articles - BL Direct - All 6 versions
R Belfort, SA Harrison, K Brown, C Darland, J … - New England Journal …, 2006 - content.nejm.org Methods We randomly assigned 55 patients with impaired glucose tolerance or type 2 diabetes
and liver biopsy–confirmed nonalcoholic steatohepatitis to 6 months of treatment with a hypocaloric
diet (a reduction of 500 kcal per day in relation to the calculated daily intake required to ... Cited by 386 - Related articles - BL Direct - All 7 versions
E Bugianesi, E Gentilcore, R Manini, S … - American journal of …, 2005 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 271 - Related articles - All 4 versions
E Bugianesi, AJ McCullough, G Marchesini… - Hepatology, 2005 - interscience.wiley.com Insulin resistance (IR) is the pathophysiological hallmark of nonalcoholic fatty liver disease
(NAFLD), one of the most common causes of chronic liver disease in Western countries. We
review the definition of IR, the methods for the quantitative assessment of insulin action, ... Cited by 170 - Related articles - BL Direct - All 3 versions
H Yki-Järvinen - Annals of Medicine, 2005 - informahealthcare.com Insulin resistance in humans is not always accompanied by obesity, since severe insulin resistance
also characterizes patients lacking subcutaneous fat such as those with HAART‐ (highly‐active
antiretroviral therapy)‐associated lipodystrophy. Both obese and lipodystrophic patients, ... Cited by 145 - Related articles - BL Direct - All 10 versions
- ►ajcn.org AS Greenberg, MS Obin - American Journal of Clinical Nutrition, 2006 - Am Soc Nutrition Recent discoveries, notably of the hormones leptin and adiponectin, have revised the notion
that adipocytes are simply a storage depot for body energy. Instead, adipocytes are also endocrine
organs, with multiple metabolic roles in regulating whole-body physiology. Small ... Cited by 141 - Related articles - All 7 versions
JP Whitehead, AA Richards, IJ Hickman, GA … - Diabetes Obesity and …, 2006 - pt.wkhealth.com Adiponectin is a recently described adipokine that has been recognized as a key regulator of
insulin sensitivity and tissue inflammation. It is produced by adipose tissue (white and
brown) and circulates in the blood at very high concentrations. It has direct actions in liver, ... Cited by 130 - Related articles - BL Direct - All 6 versions
JB Schwimmer, MS Middleton, R Deutsch, JE … - Alimentary …, 2005 - pt.wkhealth.com Results: Ten obese children (mean body mass index 30.4) enrolled and completed the trial. Mean
alanine aminotransferase and aspartate aminotransferase (AST) improved significantly (P <
0.01) from baseline (184, 114 U/L) to end of treatment (98, 68 U/L). Alanine ... Cited by 131 - Related articles - All 7 versions
- ►endojournals.org KM Utzschneider, SE Kahn - Journal of Clinical Endocrinology & …, 2006 - Endocrine Soc Evidence Synthesis: Insulin resistance in NAFLD is characterized by reductions in
whole-body, hepatic, and adipose tissue insulin sensitivity. The mechanisms underlying the accumulation
of fat in the liver may include excess dietary fat, increased delivery of free fatty acids to the ... Cited by 116 - Related articles - BL Direct - All 4 versions
BA Neuschwander-Tetri - Clinics in liver disease, 1998 - Elsevier This article considers the causes and consequences of benign steatosis and NASH, realizing
that much like the syndrome of “chronic active hepatitis” of the past decades, the syndromes
of steatosis are causally multifactorial and are subject to division into specific subsets, ... Cited by 100 - Related articles - BL Direct - All 5 versions
