- ►harvard.edu [PDF] M Stumvoll, BJ Goldstein, TW van Haeften - The Lancet, 2005 - Elsevier Type 2 diabetes mellitus has become an epidemic, and virtually no physician is without patients
who have the disease. Whereas insulin insensitivity is an early phenomenon partly related to
obesity, pancreas β-cell function declines gradually over time already before the onset of ... Cited by 441 - Related articles - All 17 versions
DJ Drucker, MA Nauck - The Lancet, 2006 - Elsevier Glucagon-like peptide 1 (GLP-1) is a gut-derived incretin hormone that stimulates insulin and
suppresses glucagon secretion, inhibits gastric emptying, and reduces appetite and food
intake. Therapeutic approaches for enhancing incretin action include ... Cited by 416 - Related articles - All 10 versions
J Rosenstock, R Brazg, PJ Andryuk, K Lu, P Stein - Clinical therapeutics, 2006 - Elsevier This was a 24-week, multicenter, ran domized, double-blind, placebo-controlled, parallel group
study in patients aged ≥18 years (ClinicalTrials. gov NCT00086502). At screening, all patients
began a diet/exercise program that continued throughout the study period. Patients taking ... Cited by 164 - Related articles - All 4 versions
C Zhang, L Qi, DJ Hunter, JB Meigs, JAE Manson, RM … - Diabetes, 2006 - Am Diabetes Assoc Emerging evidence indicates that variation in the transcription factor 7-like 2 (TCF7L2) gene
may play a role in the pathogenesis of type 2 diabetes. In a prospective, nested, case-control
study (n = 3,520) within the Nurses' Health Study (687 type 2 diabetic case and 1,051 ... Cited by 115 - Related articles - BL Direct - All 5 versions
GA Herman, C Stevens, K Van Dyck, A Bergman, … - Clinical Pharmacology & …, 2005 - nature.com Background: Sitagliptin (MK-0431 [(2R)-4-oxo-4-(3-[trifluoromethyl]-5,6-dihydro[1,2,4]triazolo[
4,3-a]pyrazin-7[8H]-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine]) is an orally active, potent, and
selective inhibitor of dipeptidyl peptidase IV (DPP-IV) currently in phase III development ... Cited by 115 - Related articles - All 6 versions
R Scott, M Wu, M Sanchez, P Stein - International journal of …, 2007 - interscience.wiley.com The aim of this study was to assess the efficacy and tolerability of the dipeptidyl peptidase-4
inhibitor, sitagliptin, in patients with type 2 diabetes who have inadequate glycaemic control on
diet and exercise. In a randomised, double-blind, placebo- and active-controlled study, ... Cited by 100 - Related articles - BL Direct - All 5 versions
- ►endojournals.org BL Wajchenberg - Endocrine reviews, 2007 - Endocrine Soc There is a progressive deterioration in ß-cell function and mass in type 2 diabetics. It was found
that islet function was about 50% of normal at the time of diagnosis, and a reduction in ß-cell
mass of about 60% was shown at necropsy. The reduction of ß-cell mass is attributable to ... Cited by 105 - Related articles - BL Direct - All 7 versions
AJ Bergman, C Stevens, YY Zhou, B Yi, M Laethem, M … - Clinical therapeutics, 2006 - Elsevier This double-blind, randomized, placebo-controlled,incremental oral-dose study was conducted
at SGS Biopharma, Antwerp, Belgium. Healthy, nonsmoking male volunteers aged 18 to 45 years
with a creatinine clearance rate of >80 mL/min and normoglycemia and weighing within ... Cited by 94 - Related articles - All 4 versions
MC Riddle, DJ Drucker - Diabetes Care, 2006 - Am Diabetes Assoc Current therapies for type 2 diabetes are frequently associated with inadequate control of postprandial
hyperglycemia, weight gain, and, in the case of oral agents, loss of efficacy over time. A better
understanding of physiological responses to meals is leading to the development of new ... Cited by 72 - Related articles - BL Direct - All 10 versions
BE Dunning, JE Foley, B Ahren - Diabetologia, 2005 - Springer Abstract Although there is abundant evidence that hyper- glucagonaemia plays a key role in
the development of hy- perglycaemia in type 2 diabetes, efforts to understand and correct this
abnormality have been overshadowed by the emphasis on insulin secretion and action. ... Cited by 70 - Related articles - BL Direct - All 3 versions
