JC Schisler, PB Jensen, DG Taylor, TC … - Proceedings of the …, 2005 - National Acad Sciences We have previously described rat insulinoma INS-1-derived cell lines with robust or poor
glucose-stimulated insulin secretion (GSIS). In the current study, we have further resolved these
lines into three classes: class 1, glucose-unresponsive/glucagon-expressing; class 2, ... Cited by 55 - Related articles - All 11 versions
SM Ronnebaum, O Ilkayeva, SC Burgess, JW … - Journal of Biological …, 2006 - ASBMB Glucose-stimulated insulin secretion (GSIS) from pancreatic islet β-cells is central to control of
mammalian fuel homeostasis. Glucose metabolism mediates GSIS in part via ATP-regulated
K + (K ATP ) channels, but multiple lines of evidence suggest participation of other ... Cited by 42 - Related articles - All 5 versions
- ►jbc.org W Cao, QF Collins, TC Becker, J Robidoux, EG … - Journal of Biological …, 2005 - ASBMB Hepatic gluconeogenesis is essential for maintaining blood glucose levels during fasting and
is the major contributor to postprandial and fasting hyperglycemia in diabetes. Gluconeogenesis
is a classic cAMP/protein kinase A-dependent process initiated by glucagon, which is ... Cited by 40 - Related articles - BL Direct - All 5 versions
- ►pnas.org S Chen, J Ding, R Bekeredjian, B Yang, … - Proceedings of the …, 2006 - National Acad Sciences This study describes a method of gene delivery to pancreatic islets of adult, living animals by
ultrasound targeted microbubble destruction (UTMD). The technique involves incorporation of
plasmids into the phospholipid shell of gas-filled microbubbles, which are then infused ... Cited by 41 - Related articles - BL Direct - All 9 versions
T Iype, J Francis, JC Garmey, JC Schisler, R … - Journal of Biological …, 2005 - ASBMB The homeodomain factor Pdx-1 regulates an array of genes in the developing and mature
pancreas, but whether regulation of each specific gene occurs by a direct mechanism (binding
to promoter elements and activating basal transcriptional machinery) or an indirect ... Cited by 34 - Related articles - All 4 versions
MV Jensen, JW Joseph, O Ilkayeva, S Burgess, D … - Journal of Biological …, 2006 - ASBMB We have previously reported that glucose-stimulated insulin secretion (GSIS) is tightly correlated
with pyruvate carboxylase (PC)-catalyzed anaplerotic flux into the tricarboxylic acid cycle and
stimulation of pyruvate cycling activity. To further evaluate the role of PC in β-cell function, ... Cited by 33 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org AS Narang, RI Mahato - Pharmacological reviews, 2006 - ASPET Islet transplantation may be used to treat type I diabetes. Despite tremendous progress in islet
isolation, culture, and preservation, the clinical use of this modality of treatment is limited due
to post-transplantation challenges to the islets such as the failure to revascularize and ... Cited by 32 - Related articles - BL Direct - All 13 versions
- ►jbc.org J Diao, Z Asghar, CB Chan, MB Wheeler - Journal of Biological Chemistry, 2005 - ASBMB The insulin receptor (IR) and its signaling appear to be essential for insulin secretion from pancreatic
-cells. However, much less is known about the role of the IR in -cells. To assess the role of the
IR in glucagon and insulin secretion, we engineered adeno-viruses for high efficiency ... Cited by 32 - Related articles - BL Direct - All 6 versions
JW Joseph, MV Jensen, O Ilkayeva, F Palmieri, C … - Journal of Biological …, 2006 - ASBMB Glucose-stimulated insulin secretion (GSIS) is mediated in part by glucose metabolism-driven
increases in ATP/ADP ratio, but by-products of mitochondrial glucose metabolism also play an
important role. Here we investigate the role of the mitochondrial citrate/isocitrate carrier ... Cited by 29 - Related articles - All 7 versions
