- ►sapo.pt [PDF] JP Bastard, M Maachi, C Lagathu, MJ Kim, M … - Eur Cytokine …, 2006 - john-libbey-eurotext.fr Auteur(s) : Jean-Philippe Bastard, Mustapha Maachi, Claire Lagathu, Min Ji Kim, Martine
Caron, Hubert Vidal, Jacqueline Capeau, Bruno Feve , Inserm U680, Faculté de Médecine Pierre
et Marie Curie, site Saint-Antoine, Université Pierre et Marie Curie, Paris 6 et Service de ... Cited by 264 - Related articles - All 7 versions
P Gual, Y Le Marchand-Brustel, JF Tanti - Biochimie, 2005 - Elsevier This review will provide insight on the current understanding of the regulation of insulin signaling
in both physiological and pathological conditions through modulations that occur with regards
to the functions of the insulin receptor substrate 1 (IRS1). While the phosphorylation of ... Cited by 159 - Related articles - All 3 versions
- ►ahajournals.org YH Yu, HN Ginsberg - Circulation research, 2005 - Am Heart Assoc For many years adipose tissue was viewed as the site where excess energy was stored, in the
form of triglycerides (TGs), and where that energy, when needed elsewhere in the body, was
released in the form of fatty acids (FAs). Recently, it has become clear that when the ... Cited by 108 - Related articles - All 7 versions
PJ Klover, AH Clementi, RA Mooney - Endocrinology, 2005 - Endocrine Soc Obesity and insulin resistance are considered chronic inflammatory states, in part because circulating
IL-6 is elevated. Exogenous IL-6 can induce hepatic insulin resistance in vitro and in vivo. The
importance of endogenous IL-6, however, to insulin resistance of obesity is unresolved. ... Cited by 93 - Related articles - BL Direct - All 5 versions
OP Kristiansen, T Mandrup-Poulsen - Diabetes, 2005 - Am Diabetes Assoc Inflammatory mechanisms play a key role in the pathogenesis of type 1 diabetes. Individuals
who progress to type 2 diabetes display features of low-grade inflammation years in advance
of disease onset. This low-grade inflammation has been proposed to be involved in the ... Cited by 72 - Related articles - BL Direct - All 5 versions
… , C PIPERI, C KALOFOUTIS, J SINGH, A … - Annals of the New …, 2006 - ingentaconnect.com Population-based studies have shown strong relationship between inflammatory markers and
metabolic disturbances, obesity, and atherosclerosis, whereas inflammation has been considered
as a “common soil” between these clinical entities and type 2 diabetes (T2D). The ... Cited by 51 - Related articles - BL Direct - All 4 versions
YW Asmann, CS Stump, KR Short, JM Coenen- … - Diabetes, 2006 - Am Diabetes Assoc We investigated whether previously reported muscle mitochondrial dysfunction and altered gene
transcript levels in type 2 diabetes might be secondary to abnormal blood glucose and insulin
levels rather than an intrinsic defect of type 2 diabetes. A total of 13 type 2 diabetic and 17 ... Cited by 49 - Related articles - BL Direct - All 5 versions
- ►physiology.org C Weigert, AM Hennige, K Brodbeck, HU … - American Journal of …, 2005 - Am Physiological Soc Previous studies showed an insulin-"desensitizing" action of IL-6 on glycogen synthesis in
hepatocytes. We recently found no inhibition of the proximal steps of the insulin signal cascade
in human skeletal muscle cells. Because these data indicate a possible tissue-specific ... Cited by 46 - Related articles - BL Direct - All 4 versions
B Antuna-Puente, B Feve, S Fellahi, JP Bastard - Diabetes and Metabolism, 2008 - Elsevier White adipose tissue was believed to be just an energy-storage organ, but it is now recognized
to be an active participant in energy homoeostasis and physiological functions such as immunity
and inflammation. Macrophages are components of adipose tissue and actively ... Cited by 51 - Related articles - BL Direct - All 3 versions
C Bonnard, A Durand, S Peyrol, E … - The Journal of …, 2008 - pubmedcentral.nih.gov Mitochondrial dysfunction in skeletal muscle has been implicated in the development of type
2 diabetes. However, whether these changes are a cause or a consequence of insulin resistance
is not clear. We investigated the structure and function of muscle mitochondria during the ... Cited by 53 - Related articles - BL Direct - All 8 versions
