- ►diabetesjournals.org M Cnop, N Welsh, JC Jonas, A Jörns, S Lenzen … - Diabetes, 2005 - Am Diabetes Assoc Type 1 and type 2 diabetes are characterized by progressive β-cell failure.
Apoptosis is probably the main form of β-cell death in both forms of the
disease. It has been suggested that the mechanisms leading to nutrient- and ... Cited by 169 - Related articles - BL Direct - All 10 versions
- ►ahajournals.org J Gutierrez, SW Ballinger, VM Darley-Usmar, … - Circulation research, 2006 - Am Heart Assoc Mitochondria have long been known to play a critical role in maintaining the
bioenergetic status of cells under physiological conditions. It was also
recognized early in mitochondrial research that the reduction of oxygen to ... Cited by 72 - Related articles - All 10 versions
- ►diabetesjournals.org WH Kim, JW Lee, YH Suh, SH Hong, JS Choi, … - Diabetes, 2005 - Am Diabetes Assoc Chronic hyperglycemia is toxic to pancreatic ß-cells, impairing cellular
functioning as observed in type 2 diabetes; however, the mechanism underlying
ß-cell dysfunction and the resulting apoptosis via glucose toxicity are ... Cited by 39 - Related articles - BL Direct - All 9 versions
J Pi, Y Bai, Q Zhang, V Wong, LM Floering, K … - Diabetes, 2007 - Am Diabetes Assoc One of the unique features of β-cells is their relatively low expression of
many antioxidant enzymes. This could render β-cells susceptible to oxidative
damage but may also provide a system that is sensitive to reactive oxygen ... Cited by 35 - Related articles - BL Direct - All 6 versions
D Morgan, HR Oliveira-Emilio, D Keane, AE … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis Acute or chronic exposure of beta cells to glucose,
palmitic acid or pro-inflammatory cytokines will result in increased production
of the p47 phox component of the NADPH oxidase and subsequent production of ... Cited by 25 - Related articles - BL Direct - All 4 versions
S Zraika, K Aston-Mourney, DR Laybutt, M … - Diabetologia, 2006 - Springer Page 1. Diabetologia (2006) 49: 1254–1263 DOI 10.1007/s00125-006-0212-9 ARTICLE
S. Zraika . K. Aston-Mourney . DR Laybutt . M. Kebede . ME Dunlop . ... Cited by 17 - Related articles - BL Direct - All 3 versions
JJ Meier, RA Ritzel, K Maedler, T Gurlo, PC … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis: Beta cell destruction in type 1 diabetes is apparently
mediated by the release of cytokines. We questioned whether cytokine-induced
apoptosis pref- erentially kills replicating beta cells. Materials and ... Cited by 16 - Related articles - BL Direct - All 3 versions
S Lenzen - Biochemical Society Transactions, 2008 - biochemsoctrans.org Antioxidative defence mechanisms of pancreatic β-cells are particularly weak
and can be overwhelmed by redox imbalance arising from overproduction of
reactive oxygen and reactive nitrogen species. The consequences of this ... Cited by 15 - Related articles - Cached - BL Direct - All 6 versions
C McCabe, A Samali, TO'Brien - Biochemical and Biophysical Research …, 2006 - Elsevier Cytokine-induced β cell destruction may be mediated by the generation of nitric
oxide and/or reactive oxygen species. The relative importance of NO and ROS in
cytokine-induced β cell pathophysiology remains unclear. This ... Cited by 12 - Related articles - All 5 versions
S Lortz, E Gurgul-Convey, S Lenzen, M … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Free radicals generated in mi- tochondria play a
crucial role in the toxic effects of cy- tokines upon insulin-producing cells.
This study therefore investigated the role of manganese superoxide ... Cited by 11 - Related articles - BL Direct - All 3 versions
