- ►jbc.org JY Lee, M Ristow, X Lin, MF White, MA Magnuson, … - Journal of Biological …, 2006 - ASBMB The Cre/loxP recombinase system for performing conditional gene targeting experiments has been very
useful in exploring genetic pathways that control both the development and function of pancreatic
-cells. One particular line of ... Cited by 52 - Related articles - BL Direct - All 8 versions
- ►physiology.org SW Limesand, J Jensen, JC Hutton, WW … - American Journal of …, 2005 - Am Physiological Soc Human fetuses with severe intrauterine growth restriction (IUGR) have less pancreatic endocrine
tissue and exhibit -cell dysfunction, which may limit -cell function in later life and contribute to
their increased incidence of ... Cited by 31 - Related articles - BL Direct - All 6 versions
- ►nih.gov [PDF] A de Vries, MC Holmes, A Heijnis, JV Seier … - Journal of Clinical …, 2007 - Am Soc Clin Investig Prenatal stress or glucocorticoid administration has persisting “programming” effects on
offspring in rodents and other model species. Multiple doses of glucocorticoids are in widespread
use in obstetric practice. To ... Cited by 28 - Related articles - BL Direct - All 9 versions
- ►uclouvain.be [PDF] B Reusens, C Remacle - International Journal of Biochemistry and Cell Biology, 2006 - Elsevier A substantial body of evidence now suggests that poor intrauterine milieu elicited by maternal
nutritional disturbance or placental insufficiency may programme susceptibility in the foetus to
later develop chronic degenerative ... Cited by 24 - Related articles - All 6 versions
A Drake, J Tang, M Nyirenda - Clinical Science, 2007 - submit.clinsci.org Compelling epidemiological evidence suggests that exposure to an adverse intrauterine environment,
manifested by low-birth weight, is associated with cardiometabolic and behavioural disorders in
adulthood. These observations have ... Cited by 21 - Related articles - Cached - BL Direct - All 7 versions
- ►physiology.org J Mairesse, J Lesage, C Breton, B Breant, … - American Journal of …, 2007 - Am Physiological Soc Prenatal stress (PS) can cause early and long-term developmental effects resulting in part from
altered maternal and/or fetal glucocorticoid exposure. The aim of the present study was to assess
the impact of chronic restraint ... Cited by 17 - Related articles - BL Direct - All 6 versions
B Breant, E Gesina, B Blondeau - Horm Res, 2006 - content.karger.com Low birth weight is strongly predictive of hypertension, cardiovascular diseases, obesity, insulin
resistance and diabetes. The mechanisms by which fetal undernutrition and, hence, low birth weight
increase the risk of developing ... Cited by 16 - Related articles - BL Direct - All 5 versions
C Remacle, O Dumortier, V Bol, K Goosse, P … - Diabetes Obes …, 2007 - interscience.wiley.com Epidemiological studies have revealed strong relationships between poor foetal growth and subsequent
development of the metabolic syndrome. Persisting effects of early malnutrition become translated
into pathology, thereby determine ... Cited by 13 - Related articles - All 2 versions
SF Witchel, DB DeFranco - Nature Reviews Endocrinology, 2006 - nature.com Glucocorticoids exert their effects in target tissues predominantly through their interaction with
the glucocorticoid receptor, a member of the nuclear receptor superfamily of transcription factors.
Over the years many studies have ... Cited by 12 - Related articles - BL Direct - All 3 versions
JA Owens, KL Gatford, MJ De Blasio, LJ … - The Journal of …, 2007 - Physiological Soc Restricted growth before birth is associated with impaired insulin secretion but with initially
enhanced insulin sensitivity in early postnatal life, which then progresses to insulin resistance
and impaired glucose homeostasis by ... Cited by 10 - Related articles - BL Direct - All 8 versions
