- ►musc.edu [PDF] JJ Lemasters, E Holmuhamedov - BBA-Molecular Basis of Disease, 2006 - Elsevier Despite a detailed understanding of their metabolism, mitochondria often behave
anomalously. In particular, global suppression of mitochondrial metabolism and
metabolite exchange occurs in apoptosis, ischemia and anoxia, cytopathic ... Cited by 70 - Related articles - All 6 versions
- ►shouxi.net AL Gloyn, S Odili, D Zelent, C Buettger, HAJ … - Journal of Biological Chemistry, 2005 - ASBMB Glucokinase (GCK) serves as the pancreatic glucose sensor. Heterozygous
inactivating GCK mutations cause hyperglycemia, whereas activating mutations
cause hypoglycemia. We studied the GCK V62M mutation identified in two ... Cited by 31 - Related articles - All 7 versions
- ►diabetesjournals.org JV Sagen, S Odili, L Bjørkhaug, D Zelent, C … - Diabetes, 2006 - Am Diabetes Assoc Glucokinase functions as a glucose sensor in pancreatic β-cells and regulates
hepatic glucose metabolism. A total of 83 probands were referred for a
diagnostic screening of mutations in the glucokinase (GCK) gene. We found ... Cited by 20 - Related articles - BL Direct - All 5 versions
Y Brunner, Y Coute, M Iezzi, M Foti, M … - Molecular & Cellular Proteomics, 2007 - ASBMB Insulin secretory granules (ISGs) are cytoplasmic organelles of pancreatic
ß-cells. They are responsible for the storage and secretion of insulin. To
date, only about 30 different proteins have been clearly described to be ... Cited by 16 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org JD Wikstrom, SM Katzman, H Mohamed, G Twig, … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—β-Cell response to glucose is characterized by mitochondrial
membrane potential (ΔΨ) hyperpolarization and the production of metabolites
that serve as insulin secretory signals. We have previously shown that ... Cited by 11 - Related articles - BL Direct - All 3 versions
- ►ncl.ac.uk [PDF] C Arden, S Baltrusch, L Agius - FEBS letters, 2006 - Elsevier The association of glucokinase with liver mitochondria has been reported [Danial
et al. (2003) BAD and glucokinase reside in a mitochondrial complex that
integrates glycolysis and apoptosis. Nature 424, 952–956]. We confirmed ... Cited by 10 - Related articles - All 12 versions
- ►endojournals.org S Baltrusch, S Langer, L Massa, M Tiedge, S … - Endocrinology, 2006 - Endocrine Soc The glucose sensor enzyme glucokinase plays a pivotal role in the regulation of
glucose-induced insulin secretion in pancreatic ß-cells. Activation of
glucokinase represents a promising concept for the treatment of type 2 ... Cited by 8 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org C Arden, A Trainer, N de la Iglesia, KT … - Diabetes, 2007 - Am Diabetes Assoc Mutations in the glucokinase (GK) gene cause defects in blood glucose
homeostasis. In some cases (V62M and G72R), the phenotype cannot be explained by
altered enzyme kinetics or protein instability. We used transient and ... Cited by 7 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org S Baltrusch, M Tiedge - Diabetes, 2006 - Am Diabetes Assoc The low-affinity glucose-phosphorylating enzyme glucokinase (GK) is the
flux-limiting glucose sensor in liver and β-cells of the pancreas. Furthermore,
GK is also expressed in various neuroendocrine cell types. This review ... Cited by 6 - Related articles - BL Direct - All 4 versions
- ►jbc.org SM Ronnebaum, JW Joseph, O Ilkayeva, SC … - Journal of Biological Chemistry, 2008 - ASBMB Acetyl-CoA carboxylase 1 (ACC1) currently is being investigated as a target for
treatment of obesity-associated dyslipidemia and insulin resistance. To
investigate the effects of ACC1 inhibition on insulin secretion, three ... Cited by 5 - Related articles - All 4 versions
