S Boudina, ED Abel - Circulation, 2007 - Am Heart Assoc The prevalence of diabetes mellitus is growing rapidly. It is estimated that
globally the number of adults affected with diabetes will increase from 135
million in 1995 to 300 million by 2025. 1 Patients with diabetes mellitus ... Cited by 135 - Related articles - All 5 versions
IG Poornima, P Parikh, RP Shannon - Circulation research, 2006 - Am Heart Assoc Although diabetes is recognized as a potent and prevalent risk factor for
ischemic heart disease, less is known as to whether diabetes causes an altered
cardiac phenotype independent of coronary atherosclerosis. Left ventricular ... Cited by 112 - Related articles - All 7 versions
- ►ahajournals.org S Boudina, S Sena, BT O'Neill, P Tathireddy, … - Circulation, 2005 - Am Heart Assoc Methods and Results— Cardiac function, M O 2 , mitochondrial respiration, and
ATP synthesis were measured in 9-week-old ob/ob and control mouse hearts.
Contractile function and M O 2 in glucose-perfused ob/ob hearts were ... Cited by 75 - Related articles - All 10 versions
AN Carley, DL Severson - BBA-Molecular and Cell Biology of Lipids, 2005 - Elsevier The metabolic phenotype of hearts has been investigated using rodent models of
type 2 diabetes which exhibit obesity and insulin resistance: db/db and ob/ob
mice, and Zucker fatty and ZDF rats. In general, cardiac fatty acid (FA) ... Cited by 73 - Related articles - All 3 versions
- ►endojournals.org J Buchanan, PK Mazumder, P Hu, G … - Endocrinology, 2005 - Endocrine Soc Hyperglycemia is associated with altered myocardial substrate use, a condition
that has been hypothesized to contribute to impaired cardiac performance. The
goals of this study were to determine whether changes in cardiac ... Cited by 69 - Related articles - BL Direct - All 5 versions
D An, B Rodrigues - American Journal of Physiology- Heart and Circulatory …, 2006 - Am Physiological Soc In patients with diabetes, an increased risk of symptomatic heart failure
usually develops in the presence of hypertension or ischemic heart disease.
However, a predisposition to heart failure might also reflect the effects ... Cited by 65 - Related articles - BL Direct - All 5 versions
OJ How, E Aasum, DL Severson, WY Chan, … - Diabetes, 2006 - Am Diabetes Assoc Altered cardiac metabolism and function (diabetic cardiomyopathy) has been
observed in diabetes. We hypothesize that cardiac efficiency, the ratio of
cardiac work (pressure-volume area [PVA]) and myocardial oxygen consumption ... Cited by 57 - Related articles - BL Direct - All 5 versions
DM Ouwens, C Boer, M Fodor, P De Galan, … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Diabetic cardiomyopathy (DCM) is common in type 2
diabetes. In DCM, insulin resistance may alter cardiac substrate supply and
utilisation leading to changes in myocardial metabolism and cardiac func- ... Cited by 46 - Related articles - All 4 versions
- ►diabetesjournals.org S Boudina, S Sena, H Theobald, X Sheng, JJ … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—db/db hearts exhibited reduced cardiac function and increased MVo 2 .
Mitochondrial reactive oxygen species (ROS) generation and lipid and protein
peroxidation products were increased. Mitochondrial proliferation was ... Cited by 41 - Related articles - BL Direct - All 4 versions
- ►physiology.org P Wang, SG Lloyd, H Zeng, A Bonen, JC … - American Journal of Physiology- Heart and Circulatory …, 2005 - Am Physiological Soc The goal of this study was to determine whether changes in cardiac metabolism in
Type 2 diabetes are associated with contractile dysfunction or impaired response
to ischemia. Hearts from Zucker diabetic fatty (ZDF) and lean control rats ... Cited by 39 - Related articles - BL Direct - All 4 versions
