C Gerhardinger, MB Costa, MC Coulombe, I Toth, T … - … ophthalmology & visual …, 2005 - ARVO RESULTS. Gene expression profiling identified 78 genes as differentially expressed in diabetic
Müller cells. One third of these genes were associated with inflammation, including a large cluster
(18% of the differentially expressed genes) of acute-phase response proteins: 2 - ... Cited by 75 - Related articles - All 6 versions
IG Obrosova, P Pacher, C Szabó, Z Zsengeller, H … - Diabetes, 2005 - Am Diabetes Assoc This study evaluated the effects of aldose reductase inhibition on diabetes-induced
oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation. In animal
experiments, control and streptozotocin-induced diabetic rats were treated with or without ... Cited by 73 - Related articles - All 8 versions
- ►diabetesjournals.org JM Cacicedo, S Benjachareowong, E Chou, NB … - Diabetes, 2005 - Am Diabetes Assoc Apoptosis of pericytes (PCs) is an early event in diabetic retinopathy. It is generally thought to
be a consequence of sustained hyperglycemia. In keeping with this, long-term (>7 days) incubation
of cultured PCs in a high-glucose media has been shown to increase apoptosis. We ... Cited by 48 - Related articles - All 6 versions
- ►diabetesjournals.org W Sun, PJ Oates, JB Coutcher, C Gerhardinger, M … - Diabetes, 2006 - Am Diabetes Assoc Previously studied inhibitors of aldose reductase were largely from two chemical classes,
spirosuccinamide/hydantoins and carboxylic acids. Each class has its own drawbacks regarding
selectivity, in vivo potency, and human safety; as a result, the pathogenic role of aldose ... Cited by 38 - Related articles - BL Direct - All 7 versions
E Berrone, E Beltramo, C Solimine, AU Ape, M … - Journal of Biological …, 2006 - ASBMB Hyperglycemia is a causal factor in the development of the vascular complications of
diabetes. One of the biochemical mechanisms activated by excess glucose is the polyol
pathway, the key enzyme of which, aldose reductase, transforms d-glucose into d-sorbitol, ... Cited by 38 - Related articles - BL Direct - All 7 versions
SSM Chung, SK Chung - Current Drug Targets, 2005 - ingentaconnect.com Abstract: Most long-term diabetic patients develop microvascular diseases such as
retinopathy, nephropathy and neuropathy. Although tight control of blood glucose greatly reduces
the incidence of these complications, a significant fraction of diabetic patients with good ... Cited by 38 - Related articles - All 2 versions
PJ Oates - Current drug targets, 2008 - ingentaconnect.com Abstract: Aldose reductase (AR) enzymatically transforms cytosolic glucose into sorbitol, a molecule
that poorly pene- trates cell membranes and is sometimes slowly metabolized. Hyperglycemia
can cause intracellular accumulation of sorbi- tol and its metabolite, fructose, which can ... Cited by 26 - Related articles - BL Direct - All 3 versions
W Sun, C Gerhardinger, Z Dagher, T Hoehn, M Lorenzi - Diabetes, 2005 - Am Diabetes Assoc The prevention of diabetic retinopathy requires drugs that leverage the benefits of glycemic control
without adding the burden of side effects. Aspirin at dosages of 1–1.5 g/day has prevented manifestations
of diabetic retinal microangiopathy in a clinical trial as well as in studies with dogs. ... Cited by 24 - Related articles - BL Direct - All 6 versions
