DJ Drucker, MA Nauck - The Lancet, 2006 - Elsevier Glucagon-like peptide 1 (GLP-1) is a gut-derived incretin hormone that
stimulates insulin and suppresses glucagon secretion, inhibits gastric emptying,
and reduces appetite and food intake. Therapeutic approaches for enhancing ... Cited by 408 - Related articles - All 10 versions
- ►rh.dk [PDF] LL Baggio, DJ Drucker - Gastroenterology, 2007 - Elsevier This review focuses on the mechanisms regulating the synthesis, secretion,
biological actions, and therapeutic relevance of the incretin peptides
glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like ... Cited by 173 - Related articles - All 25 versions
- ►endojournals.org T Talsania, Y Anini, S Siu, DJ Drucker, PL … - Endocrinology, 2005 - Endocrine Soc Glucagon-like peptide-1 7–36NH2 (GLP-1) and peptide YY 3–36NH2 (PYY
3–36NH2 ) are cosecreted from the intestine in response to nutrient ingestion.
Peripheral administration of GLP-1 or PYY 3–36NH2 decreases food intake ... Cited by 86 - Related articles - BL Direct - All 6 versions
- ►glucagon.com [PDF] - Free from Publisher MC Riddle, DJ Drucker - Diabetes Care, 2006 - Am Diabetes Assoc Current therapies for type 2 diabetes are frequently associated with inadequate
control of postprandial hyperglycemia, weight gain, and, in the case of oral
agents, loss of efficacy over time. A better understanding of physiological ... Cited by 71 - Related articles - BL Direct - All 10 versions
DJ Drucker - Nature Clinical Practice Endocrinology and Metabolism, 2005 - glucagon.com INTRODUCTION Before the cDNAs and genes encoding pro glucagon were cloned,
pancreatic glucagon was the prin- cipal proglucagon-derived peptide (PGDP) with
well-characterized biologic actions. However, antisera directed against ... Cited by 59 - Related articles - View as HTML - BL Direct - All 6 versions
- ►physiology.org LA Nikolaidis, D Elahi, YT Shen, RP Shannon - American Journal of Physiology- Heart and Circulatory …, 2005 - Am Physiological Soc We have shown previously that the glucagon-like peptide-1 (GLP-1)-(7–36) amide
increases myocardial glucose uptake and improves left ventricular (LV) and
systemic hemodynamics in both conscious dogs with pacing-induced dilated ... Cited by 39 - Related articles - BL Direct - All 5 versions
- ►physiology.org EM Sinclair, DJ Drucker - Physiology, 2005 - Am Physiological Soc The proglucagon-derived peptides (PGDPs) are encoded by a single mammalian
proglucagon gene. Tissue-specific posttranslational processing mediated by
prohormone convertase (PC) enzymes liberates these peptide hormones in a ... Cited by 29 - Related articles - All 4 versions
AK Sato, M Viswanathan, RB Kent, CR Wood - Current opinion in biotechnology, 2006 - Elsevier As potential therapeutics, peptides offer several advantages over small
molecules (increased specificity) and antibodies (small size). Nevertheless, a
number of key issues have hampered their use as drug candidates. A series ... Cited by 27 - Related articles - All 5 versions
GM Subramanian, M Fiscella, A Lamousé- … - Nature biotechnology, 2007 - nature.com Treatment regimens based on the use of interferon- (IFN- ) remain the
cornerstone of therapy for chronic hepatitis C virus infection, which affects
nearly 170 million people worldwide. Treatment options include unmodified ... Cited by 25 - Related articles - BL Direct - All 4 versions
- ►qub.ac.uk [PDF] BD Green, PR Flatt - Best Practice & Research Clinical Endocrinology & …, 2007 - Elsevier The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent
insulinotropic polypeptide (GIP) are physiological gut peptides with
insulin-releasing and extrapancreatic glucoregulatory actions. Incretin ... Cited by 29 - Related articles - All 17 versions
