MD Brand, C Affourtit, TC Esteves, K Green, AJ … - Free Radical Biology and …, 2004 - Elsevier Mitochondria are potent producers of cellular superoxide, from complexes I and III of the electron
transport chain, and mitochondrial superoxide production is a major cause of the cellular oxidative
damage that may underlie ... Cited by 267 - Related articles - All 6 versions
MD Brand, TC Esteves - Cell Metabolism, 2005 - Elsevier Uncoupling proteins (UCPs) have become prominent in the fields of thermogenesis, obesity, diabetes,
and free radical biology following the discovery of a family of novel UCPs and have recently started
to make an impact in the areas of ... Cited by 179 - Related articles - All 10 versions
- ►uc.pt [PDF] AP Rolo, CM Palmeira - Toxicology and applied pharmacology, 2006 - Elsevier Hyperglycemia resulting from uncontrolled glucose regulation is widely recognized as the causal link
between diabetes and diabetic complications. Four major molecular mechanisms have been implicated in
hyperglycemia-induced tissue ... Cited by 120 - Related articles - All 7 versions
H Kolb, T Mandrup-Poulsen - Diabetologia, 2005 - Springer Abstract Subclinical, low-grade systemic inflammation has been observed in patients with type 2
diabetes and in those at increased risk of the disease. This may be more than an epiphenomenon.
Alleles of genes encoding immune/ ... Cited by 118 - Related articles - BL Direct - All 5 versions
PS Brookes - Free Radical Biology and Medicine, 2005 - Elsevier The single-electron chemistry of mitochondrial oxidative phosphorylation (ox-phos) by default
generates reactive oxygen species (ROS). These ROS have roles in both physiologic cell signaling and
numerous pathologic situations. One ... Cited by 98 - Related articles - All 5 versions
- ►jbc.org Y Gorin, K Block, J Hernandez, B Bhandari, B … - Journal of Biological …, 2005 - ASBMB Renal hypertrophy and extracellular matrix accumulation are early features of diabetic nephropathy.
We investigated the role of the NAD(P)H oxidase Nox4 in generation of reactive oxygen species (ROS),
hypertrophy, and fibronectin ... Cited by 93 - Related articles - BL Direct - All 5 versions
- ►pnas.org T Yu, JL Robotham, Y Yoon - Proceedings of the National …, 2006 - National Acad Sciences Increased production of mitochondrial reactive oxygen species (ROS) by hyperglycemia is recognized
as a major cause of the clinical complications associated with diabetes and obesity [Brownlee, M.
(2001) Nature 414, 813–820]. We ... Cited by 91 - Related articles - BL Direct - All 9 versions
JS Johansen, AK Harris, DJ Rychly, A Ergul - Cardiovascular diabetology, 2005 - cardiab.com Cardiovascular complications, characterized by endothelial dysfunction and accelerated
atherosclerosis, are the leading cause of morbidity and mortality associated with diabetes. There is
growing evidence that excess ... Cited by 88 - Related articles - Cached - All 10 versions
MY Donath, JA Ehses, K Maedler, DM Schumann, H … - Diabetes, 2005 - Am Diabetes Assoc A decrease in the number of functional insulin-producing β-cells contributes to the pathophysiology
of type 2 diabetes. Opinions diverge regarding the relative contribution of a decrease in β-cell
mass versus an intrinsic defect in ... Cited by 86 - Related articles - BL Direct - All 6 versions
- ►pnas.org KM Robinson, MS Janes, M Pehar, JS … - Proceedings of the …, 2006 - National Acad Sciences The putative oxidation of hydroethidine (HE) has become a widely used fluorescent assay for the
detection of superoxide in cultured cells. By covalently joining HE to a hexyl triphenylphosphonium
cation (Mito-HE), the HE moiety can ... Cited by 82 - Related articles - BL Direct - All 11 versions
