- ►harvard.edu [PDF] M Stumvoll, BJ Goldstein, TW van Haeften - The Lancet, 2005 - Elsevier Type 2 diabetes mellitus has become an epidemic, and virtually no physician is without patients
who have the disease. Whereas insulin insensitivity is an early phenomenon partly related to
obesity, pancreas β-cell function declines gradually over time already before the onset of ... Cited by 441 - Related articles - All 17 versions
Y Nakatani, H Kaneto, D Kawamori, K Yoshiuchi, M … - Journal of Biological …, 2005 - ASBMB Type 2 diabetes is one of the most prevalent and serious metabolic diseases in the world, and
insulin resistance and pancreatic -cell dysfunction are the hallmarks of the disease. In this
study, we have shown that endoplasmic reticulum (ER) stress, which is provoked under ... Cited by 144 - Related articles - All 5 versions
Y Li, W Xu, Z Liao, B Yao, X Chen, Z Huang, G Hu, … - Diabetes Care, 2004 - Am Diabetes Assoc RESULTS—Optimal glycemic control was achieved within 6.3 ± 3.9 days by CSII in 126
patients. The remission rates (percentages maintaining near euglycemia) at the third, sixth,
twelfth, and twenty-fourth month were 72.6, 67.0, 47.1, and 42.3%, respectively. Patients ... Cited by 120 - Related articles - BL Direct - All 8 versions
H Kolb, T Mandrup-Poulsen - Diabetologia, 2005 - Springer Abstract Subclinical, low-grade systemic inflammation has been observed in patients with type
2 diabetes and in those at increased risk of the disease. This may be more than an
epiphenomenon. Alleles of genes encoding immune/ inflammatory mediators are ... Cited by 118 - Related articles - BL Direct - All 5 versions
JL Leahy - Archives of medical research, 2005 - Elsevier The pathological sequence for type 2 diabetes is complex and entails many different elements
that act in concert to cause that disease. This review proposes a sequence of events and how
they interact by a careful analysis of the human and animal model literature. A genetic ... Cited by 102 - Related articles - All 14 versions
JJ Meier, A Bhushan, AE Butler, RA Rizza, PC Butler - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Type 1 diabetes is widely held to result from an irreversible loss of
insulin-secreting beta cells. However, insulin secretion is detectable in some peo- ple with
long-standing type 1 diabetes, indicating either a small population of surviving beta cells ... Cited by 104 - Related articles - BL Direct - All 5 versions
- ►endojournals.org E Karaskov, C Scott, L Zhang, T Teodoro, M Ravazzola, … - Endocrinology, 2006 - Endocrine Soc Chronic free fatty acid (FFA) exposure induces pancreatic ß-cell death, which may contribute
to the development of type 2 diabetes. The mechanisms involved in FFA-induced cell death are
not completely understood. Here we have investigated the effect of FFA on endoplasmic ... Cited by 95 - Related articles - BL Direct - All 4 versions
- ►endojournals.org BL Wajchenberg - Endocrine reviews, 2007 - Endocrine Soc There is a progressive deterioration in ß-cell function and mass in type 2 diabetics. It was found
that islet function was about 50% of normal at the time of diagnosis, and a reduction in ß-cell
mass of about 60% was shown at necropsy. The reduction of ß-cell mass is attributable to ... Cited by 105 - Related articles - BL Direct - All 7 versions
MY Donath, JA Ehses, K Maedler, DM Schumann, H … - Diabetes, 2005 - Am Diabetes Assoc A decrease in the number of functional insulin-producing β-cells contributes to the pathophysiology
of type 2 diabetes. Opinions diverge regarding the relative contribution of a decrease in β-cell
mass versus an intrinsic defect in the secretory machinery. Here we review the evidence ... Cited by 86 - Related articles - BL Direct - All 6 versions
