- ►harvard.edu [PDF] M Stumvoll, BJ Goldstein, TW van Haeften - The Lancet, 2005 - Elsevier Type 2 diabetes mellitus has become an epidemic, and virtually no physician is
without patients who have the disease. Whereas insulin insensitivity is an early
phenomenon partly related to obesity, pancreas β-cell function declines ... Cited by 441 - Related articles - All 17 versions
WX Zong, CB Thompson - Genes & development, 2006 - genesdev.cshlp.org Organismal homeostasis depends on an intricate balance between cell death and
renewal. Early pathologists recognized that this balance could be disrupted by
the extensive damage observed in internal organs during the course of ... Cited by 154 - Related articles - BL Direct - All 7 versions
- ►biologists.org SJ Franco, A Huttenlocher - Journal of cell science, 2005 - jcs.biologists.org The calpain family of proteases has been implicated in cellular processes such
as apoptosis, proliferation and cell migration. Calpains are involved in several
key aspects of migration, including: adhesion and spreading; detachment of ... Cited by 95 - Related articles - BL Direct - All 10 versions
- ►shouxi.net M Zatz, A Starling - The New England journal of medicine, 2005 - nejm.highwire.org Calpains are Ca 2+ -dependent cysteine proteases (proteolytic enzymes with
cysteine in the catalytic site) that modulate cellular function. In humans, 14
independent genes encode members of the calpain superfamily. Some calpain ... Cited by 62 - Related articles - All 7 versions
HC Anderson, R Garimella, SE Tague - Front Biosci, 2005 - bioscience.org 1. Abstract 2. Introduction 3. Molecular components of matrix vesicles 3.1.
Lipids 3.2. Alkaline phosphatase 3.3. Other phosphatases regulating matrix
vesicle mineralization 3.4. Non-phosphatase proteins that play a role in ... Cited by 42 - Related articles - View as HTML - All 3 versions
MD Turner, PG Cassell, GA Hitman - Diabetes/Metabolism Reviews - interscience.wiley.com Calpain-10 (CAPN10) is the first diabetes gene to be identified through a genome
scan. Many investigators, but not all, have subsequently found associations
between CAPN10 polymorphism and type 2 diabetes (T2D) as well as insulin ... Cited by 38 - Related articles - BL Direct - All 3 versions
D Branca - Biochemical and Biophysical Research …, 2004 - Elsevier Calpains are calcium-modulated proteases which respond to Ca 2+ signals by
removing limited portions of protein substrates, thereby irreversibly modifying
their function(s). Members of this protease family are present in a variety ... Cited by 32 - Related articles - All 5 versions
- ►pasteur.ac.ir [PDF] HM Mehendale, PB Limaye - Trends in pharmacological sciences, 2005 - Elsevier Calpain is a Ca 2+ -regulated cytosolic cysteine protease that exists mainly in
two isoforms and mediates crucial cellular functions, including rearrangement of
cytoskeletal proteins, transport of the glucose transporter GLUT4, and ... Cited by 28 - Related articles - All 5 versions
F Paquet-Durand, S Azadi, SM Hauck, M … - Journal of neurochemistry, 2006 - interscience.wiley.com The retinal degeneration (rd)1 mouse displays an inherited retinal degeneration
and therefore allows studies of the molecular mechanisms behind the blinding
disease retinitis pigmentosa. Activation of the calcium-dependent protease ... Cited by 27 - Related articles - BL Direct - All 5 versions
R Ivarsson, X Jing, L Waselle, R Regazzi, E … - Traffic, 2005 - interscience.wiley.com We have examined the importance of the actin-based molecular motor myosin 5a for
insulin granule transport and insulin secretion. Expression of myosin 5a was
downregulated in clonal INS-1E cells using RNAinterference. Stimulated ... Cited by 27 - Related articles - BL Direct - All 3 versions
