- ►biologists.org H Wang, G Kouri, CB Wollheim - Journal of cell science, 2005 - jcs.biologists.org The reduction in insulin secretory capacity and ß-cell mass observed in type 2
diabetes is thought to be caused by glucolipotoxicity secondary to hyperglycemia
and hyperlipidemia. Our aim in this study was to elucidate the underlying ... Cited by 102 - Related articles - BL Direct - All 7 versions
JD MacLellan, MF Gerrits, A Gowing, PJS … - Diabetes, 2005 - Am Diabetes Assoc Decreased uncoupling protein (UCP)3 is associated with insulin resistance in
muscle of pre-diabetic and diabetic individuals, but the function of UCP3
remains unclear. Our goal was to elucidate mechanisms underlying the ... Cited by 79 - Related articles - BL Direct - All 9 versions
- ►aspetjournals.org MW Fariss, CB Chan, M Patel, B Van Houten, … - Molecular interventions, 2005 - ASPET Oxidative stress and mitochondrial oxidative damage have been implicated in the
etiology of numerous common diseases. The critical mitochondrial events
responsible for oxidative stress–mediated cell death (toxic oxidative ... Cited by 68 - Related articles - All 2 versions
- ►physoc.org P Newsholme, EP Haber, SM Hirabara, ELO … - The Journal of Physiology, 2007 - Physiological Soc It is now widely accepted, given the current weight of experimental evidence,
that reactive oxygen species (ROS) contribute to cell and tissue dysfunction and
damage caused by glucolipotoxicity in diabetes. The source of ROS in the ... Cited by 59 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org A Tarasov, J Dusonchet, F Ashcroft - Diabetes, 2004 - Am Diabetes Assoc Closure of ATP-sensitive K + channels (K ATP channels) is a key step in
glucose-stimulated insulin secretion. The precise mechanism(s) by which glucose
metabolism regulates K ATP channel activity, however, remains ... Cited by 47 - Related articles - BL Direct - All 4 versions
- ►fasebj.org V Bezaire, EL Seifert, ME Harper - The FASEB Journal, 2007 - FASEB Uncoupling protein (UCP) 3 (UCP3) is a mitochondrial anion carrier protein with
highly selective expression in skeletal muscle. Despite a great deal of
interest, to date neither its molecular mechanism nor its biochemical and ... Cited by 48 - Related articles - BL Direct - All 4 versions
D Ricquier - Proceedings of the Nutrition Society, 2007 - Cambridge Univ Press Metabolic energy expenditure negatively regulates energy balance. Metabolic and
catabolic pathways contribute to energy expenditure. Catabolic pathways split
C-containing molecules into small molecules and generate reduced coenzymes ... Cited by 46 - Related articles - All 7 versions
- ►cell.com T Yang, M Fu, R Pestell, AA Sauve - Trends in Endocrinology & Metabolism, 2006 - Elsevier Sirtuins (Sir2-related enzymes) are a recently discovered class of NAD +
-dependent protein deacetylases that regulate gene expression in a variety of
organisms by deacetylation of modified lysine residues on histones, ... Cited by 44 - Related articles - All 6 versions
M Anello, R Lupi, D Spampinato, S Piro, M … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Little information is available on the insulin release
properties of pancreatic islets iso- lated from type 2 diabetic subjects. Since
mitochondria represent the site where important metabolites that regulate ... Cited by 42 - Related articles - All 3 versions
G Mattiasson, PG Sullivan - Antioxidants & Redox Signaling, 2006 - liebertonline.com 1 Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center,
Lund, Sweden. 2 Spinal Cord and Brain Injury Research Center and 3 Department of
Anatomy and Neurobiology University of Kentucky, Lexington, Kentucky. Cited by 41 - Related articles - BL Direct - All 3 versions
