- ►shouxi.net AK Busch, E Gurisik, DV Cordery, M Sudlow, … - Diabetes, 2005 - Am Diabetes Assoc Increased availability of fatty acids causes cell death and dysfunction in
β-cell lines, isolated islets, and animal models of diabetes. From the MIN6
β-cell line, we selected two subpools that are resistant to ... Cited by 40 - Related articles - BL Direct - All 5 versions
E Roche, JA Reig, A Campos, B Paredes, JR … - Transplant immunology, 2005 - Elsevier Diabetes is a degenerative disease that results from the selective destruction
of pancreatic β-cells. These cells are responsible for insulin production and
secretion in response to increases in circulating concentrations of ... Cited by 24 - Related articles - All 3 versions
V Grishko, L Rachek, S Musiyenko, SP … - Free Radical Biology and Medicine, 2005 - Elsevier A growing body of evidence indicates that free fatty acids (FFA) can have
deleterious effects on β-cells. It has been suggested that the β-cell
dysfunction and death observed in diabetes may involve exaggerated ... Cited by 19 - Related articles - All 3 versions
- ►nih.gov KD Jeffrey, EU Alejandro, DS Luciani, TB … - Proceedings of the National Academy of Sciences, 2008 - National Acad Sciences Obesity is a principal risk factor for type 2 diabetes, and elevated fatty acids
reduce β-cell function and survival. An unbiased proteomic screen was used to
identify targets of palmitate in β-cell death. The most significantly ... Cited by 13 - Related articles - BL Direct - All 5 versions
- ►shouxi.net CS Olofsson, S Collins, M Bengtsson, L … - Diabetes, 2007 - Am Diabetes Assoc Mouse β-cells cultured at 15 mmol/l glucose for 72 h had reduced ATP-sensitive
K + (K ATP ) channel activity (−30%), increased voltage-gated Ca 2+ currents,
higher intracellular free Ca 2+ concentration ([Ca 2+ ] i ; +160%), more ... Cited by 10 - Related articles - BL Direct - All 5 versions
- ►jbc.org V Koshkin, FF Dai, CA Robson-Doucette, CB … - Journal of Biological Chemistry, 2008 - ASBMB Involvement of the mitochondrial permeability transition (MPT) pore in early
stages of lipotoxic stress in the pancreatic β-cell lines MIN6 and INS-1 was
the focus of this study. Both long term (indirect) and acute (direct) ... Cited by 9 - Related articles - All 4 versions
- ►uc.pt [PDF] E Nunes, F Peixoto, T Louro, CM Sena, MS … - Acta Diabetologica, 2007 - Springer Abstract We investigated the effect of sub-chronic soy- bean oil (SO) treatment
on the insulin secretion and fatty acid composition of islets of Langerhans
obtained from Goto-Kakizaki (GK), a model of type 2 diabetes, and nor- mal ... Cited by 7 - Related articles - BL Direct - All 4 versions
- ►physiology.org PO Westermark, JH Kotaleski, A Bjorklund, V … - American Journal of Physiology- Endocrinology And …, 2007 - Am Physiological Soc The pancreatic -cells respond to an increased glycolytic flux by secreting
insulin. The signal propagation goes via mitochondrial metabolism, which relays
the signal to different routes. One route is an increased ATP production ... Cited by 3 - Related articles - BL Direct - All 5 versions
- ►nih.gov A Podcheko, P Northcott, G Bikopoulos, A … - Molecular and Cellular Biology, 2007 - Am Soc Microbiol The pleckstrin homology domain-interacting protein (PHIP) was originally
identified as a 902-amino-acid (aa) protein that regulates insulin
receptor-stimulated GLUT4 translocation in skeletal-muscle cells. ... Cited by 3 - Related articles - BL Direct - All 6 versions
HM Zhang, H Dang, CK Yeh, BX Zhang, 2009 - pubmedcentral.nih.gov It is well known that excessive non-esterified fatty acids in diabetes
contribute to the pathogenesis of renal complications although the mechanism
remains elusive. Enhanced oxidative stress has been hypothesized as a ... Cited by 1 - Related articles - All 6 versions
