- ►case.edu [PDF] JH Moore, JC Gilbert, CT Tsai, FT Chiang, T Holden … - Journal of theoretical …, 2006 - Elsevier Detecting, characterizing, and interpreting gene–gene interactions or epistasis in studies of human
disease susceptibility is both a mathematical and a computational challenge. To address this
problem, we have previously developed a multifactor dimensionality reduction (MDR) ... Cited by 106 - Related articles - All 8 versions
JH Moore, SM Williams - Bioessays, 2005 - interscience.wiley.com Epistasis plays an important role in the genetic architecture of common human diseases and
can be viewed from two perspectives, biological and statistical, each derived from and leading
to different assumptions and research strategies. Biological epistasis is the result of ... Cited by 85 - Related articles - BL Direct - All 3 versions
- ►oxfordjournals.org H Freeman, RD Cox - Human molecular genetics, 2006 - Oxford Univ Press Diabetes is one of the most challenging health problems of the 21st century with an alarming
increase in the prevalence of type-2 diabetes mellitus (T2DM) and associated conditions such
as hypertension, dyslipidemias and obesity. T2DM is a complex genetic disease ... Cited by 48 - Related articles - BL Direct - All 8 versions
B Neve, ME Fernandez-Zapico, V … - Proceedings of the …, 2005 - National Acad Sciences KLF11 (TIEG2) is a pancreas-enriched transcription factor that has elicited significant attention
because of its role as negative regulator of exocrine cell growth in vitro and in vivo.
However, its functional role in the endocrine pancreas remains to be established. Here, ... Cited by 46 - Related articles - All 15 versions
SM Harwood, MM Yaqoob, DA Allen - Annals of clinical …, 2005 - acb.rsmjournals.com Caspase and calpain function in cell death: bridging the gap ... Steven M Harwood, Muhammad
M Yaqoob and David A Allen ... Addresses Centre for Experimental Medicine, Nephro- logy
and Critical Care, Renal Research Laboratories, William Harvey Research Institute, John ... Cited by 44 - Related articles - BL Direct - All 5 versions
MD Turner, PG Cassell, GA Hitman - Diabetes/Metabolism Reviews - interscience.wiley.com Calpain-10 (CAPN10) is the first diabetes gene to be identified through a genome scan. Many
investigators, but not all, have subsequently found associations between CAPN10 polymorphism
and type 2 diabetes (T2D) as well as insulin action, insulin secretion, aspects of adipocyte ... Cited by 38 - Related articles - BL Direct - All 3 versions
- ►nih.gov J Vander Molen, LM Frisse, SM Fullerton, Y Qian, L … - The American Journal of …, 2005 - Elsevier A positional cloning study of type 2 diabetes in Mexican Americans identified a region, termed
“NIDDM1,” on chromosome 2q37 with significant linkage evidence. Haplotype combinations
at the calpain-10 gene (CAPN10) within this region were shown to increase diabetes risk ... Cited by 35 - Related articles - All 6 versions
D Branca - Biochemical and Biophysical Research …, 2004 - Elsevier Calpains are calcium-modulated proteases which respond to Ca 2+ signals by removing limited
portions of protein substrates, thereby irreversibly modifying their function(s). Members of this
protease family are present in a variety of organisms ranging from mammals to plants; ... Cited by 32 - Related articles - All 5 versions
SCL Gough, MC O'Donovan - Journal of Psychopharmacology, 2005 - jop.sagepub.com People with schizophrenia are more likely to develop type 2 diabetes than the general
population. Although an increased risk of diabetes has been attributed to environmental determinants
such as diet, lifestyle and antipsychotic drugs, the association between these two ... Cited by 29 - Related articles - All 3 versions
- ►endojournals.org SM Clee, AD Attie - Endocrine reviews, 2007 - Endocrine Soc Inbred mouse strains provide genetic diversity comparable to that of the human population. Like
humans, mice have a wide range of diabetes-related phenotypes. The inbred mouse strains
differ in the response of their critical physiological functions, such as insulin sensitivity, ... Cited by 29 - Related articles - BL Direct - All 4 versions
