- ►nih.gov KI Rother, DM Harlan - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig Worldwide, more than 750 individuals with type 1 diabetes mellitus (T1DM) have received allogeneic
islet transplants since 1974, in an effort to cure their chronic condition. Though this is still a small
number (especially when compared with the estimated 1 million afflicted with T1DM and ... Cited by 103 - Related articles - BL Direct - All 11 versions
S Ullrich, S Berchtold, F Ranta, G Seebohm, G Henke, … - Diabetes, 2005 - Am Diabetes Assoc Glucocorticoid excess predisposes to the development of diabetes, at least in part through impairment
of insulin secretion. The underlying mechanism has remained elusive. We show here that dexamethasone
upregulates transcription and expression of the serum- and glucocorticoid-inducible ... Cited by 50 - Related articles - All 5 versions
- ►diabetesjournals.org JC Henquin - Diabetes, 2004 - Am Diabetes Assoc Physiologically, insulin secretion is subject to a dual, hierarchal control by triggering and amplifying
pathways. By closing ATP-sensitive K + channels (K ATP channels) in the plasma
membrane, glucose and other metabolized nutrients depolarize β-cells, stimulate Ca 2+ ... Cited by 37 - Related articles - BL Direct - All 4 versions
SR Bornstein, A Schuppenies, ML Wong, J … - Molecular psychiatry, 2006 - manpixforfit.59.to Obesity and depression are serious public health problems and also constitute cardiovascular
disease risk factors. Research organizations have called for efforts to explore the interrelationship
between obesity and depression. A useful starting point is the fact that in both disorders ... Cited by 33 - Related articles - View as HTML - BL Direct - All 8 versions
JW Tomlinson, PM Stewart - Nature clinical practice. Endocrinology & …, 2005 - ncbi.nlm.nih.gov The magnitude of the obesity and metabolic syndrome epidemic has heightened the need for
the development of new and effective treatments. Although circulating cortisol concentrations
are not elevated in obesity or in the metabolic syndrome, decreasing the tissue-specific ... Cited by 25 - Related articles - BL Direct - All 3 versions
- ►endojournals.org H Oberkofler, K Klein, TK Felder, F Krempler, W Patsch - Endocrinology, 2006 - Endocrine Soc A role of uncoupling protein 2 (UCP2) as negative modulator of insulin secretion has been
suggested, but the transcriptional pathways regulating ß-cell UCP2 gene expression have been
established in rodents only. We show here that the underlying sequence motifs are not ... Cited by 16 - Related articles - BL Direct - All 3 versions
SF Witchel, DB DeFranco - Nature Reviews Endocrinology, 2006 - nature.com Glucocorticoids exert their effects in target tissues predominantly through their interaction with
the glucocorticoid receptor, a member of the nuclear receptor superfamily of transcription
factors. Over the years many studies have linked hormone responsiveness, both in vitro ... Cited by 12 - Related articles - BL Direct - All 3 versions
- ►nih.gov E Gesina, B Blondeau, A Milet, I Le Nin, B Duchene, P … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis Beta cell development is sensitive to glucocorticoid levels. Although
direct effects of glucocorti- coids on pancreatic precursors have been shown to control beta cell
mass expansion, indirect effects of these hormones on pancreatic development remain ... Cited by 8 - Related articles - BL Direct - All 7 versions
LP Roma, A Rafacho, SR Taboga, AC … - Canadian Journal of …, 2007 - ingentaconnect.com Abstract: Augmented glucose-stimulated insulin secretion (GSIS) is an adaptive mechanism
exhibited by pancreatic islets from insulin-resistant animal models. Gap junction proteins have
been proposed to contribute to islet function. As such, we investigated the expression of ... Cited by 7 - Related articles - BL Direct - All 5 versions
- ►endocrinology-journals.org H Ghanaat-Pour, Z Huang, M Lehtihet, A … - Journal of molecular …, 2007 - Soc Endocrinology The spontaneously diabetic Goto-Kakizaki (GK) rat is frequently used as a model for human type
2 diabetes. Selective loss of glucose-sensitive insulin secretion is an early pathogenetic event
in human type 2 diabetes, and such a defect also typifies islets from the GK rat. We ... Cited by 6 - Related articles - All 3 versions
