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Scholar Results 1 - 10 of about 33 citing Sugden: Potential role of peroxisome proliferator-activated receptor-α in the modulation.... (0.10 sec) 

The MODY1 gene HNF-4α regulates selected genes involved in insulin secretion

- nih.gov
RK Gupta, MZ Vatamaniuk, CS Lee, RC … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig
Mutations in the gene encoding hepatocyte nuclear factor-4α (HNF-4α) result in
maturity-onset diabetes of the young (MODY). To determine the contribution of
HNF-4α to the maintenance of glucose homeostasis by the β cell in vivo, ...
Cited by 75 - Related articles - All 7 versions

Peroxisome Proliferator-Activated Receptor {alpha}(PPAR {alpha}) Potentiates, whereas …

- endojournals.org
K Ravnskjaer, M Boergesen, B Rubi, JK Larsen … - Endocrinology, 2005 - Endocrine Soc
Fatty acids (FAs) are known to be important regulators of insulin secretion from
pancreatic ß-cells. FA-coenzyme A esters have been shown to directly stimulate
the secretion process, whereas long-term exposure of ß-cells to FAs ...
Cited by 45 - Related articles - BL Direct - All 2 versions

The clinical applications of a systems approach


AC Ahn, M Tewari, CS Poon, RS Phillips - PLoS Med, 2006 - medicine.plosjournals.org
Funding: ACA's work on this manuscript was supported by a National Institutes of
Health Institutional National Research Service Award, grant T32-AT0051-03. RSP
is supported by a National Institutes of Health Mid-Career Investigator ...
Cited by 37 - Related articles - Cached - All 13 versions

Activation of Mouse and Human Peroxisome Proliferator-Activated Receptors ({alpha},{beta} …

- oxfordjournals.org
ML Takacs, BD Abbott - Toxicological Sciences, 2007 - Soc Toxicology
This study evaluates the potential for perfluorooctanoic acid (PFOA) and
perfluorooctane sulfonate (PFOS) to activate peroxisome proliferator–activated
receptors (PPARs), using a transient transfection cell assay. Cos-1 cells ...
Cited by 29 - Related articles - All 5 versions

[PDF] Insulin resistance in NASH


J Choudhury, AJ Sanyal - Front Biosci, 2005 - bioscience.org
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease
observed in the clinical practice of hepatology. The coexistence of metabolic
syndrome in this cohort of patients has made insulin resistance central to ...
Cited by 29 - Related articles - View as HTML - All 3 versions

Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the …

- aspetjournals.org
HL Fang, SC Strom, H Cai, CN Falany, TA … - Molecular pharmacology, 2005 - ASPET
Human hydroxysteroid sulfotransferase or (HUMAN)SULT2A1 catalyzes the
sulfonation of procarcinogen xenobiotics, hydroxysteroids, and bile acids and
plays a dynamic role in hepatic cholesterol homeostasis. The treatment of ...
Cited by 27 - Related articles - All 6 versions

Investigational PPAR-γ agonists for the treatment of type 2 diabetes


RS Savkur, AR Miller - Expert Opin. Investig. Drugs, 2006 - Informa Pharma Science
The tremendous increase in the global prevalence of Type 2 diabetes (T2D) and
its conglomeration of metabolic disorders has dramatically intensified the
search for innovative therapies to fight this emerging epidemic. Over the ...
Cited by 14 - Related articles - BL Direct - All 5 versions

[PDF] Transcriptional regulation of lipid metabolism by fatty acids: a key determinant of pancreatic β …


Z Fatehi-Hassanabad, CB Chan - Nutrition & Metabolism, 2005 - biomedcentral.com
Page 1 of 12 (page number not for citation purposes) ... Transcriptional
regulation of lipid metabolism by fatty acids: a key ... Zahra
Fatehi-Hassanabad and Catherine B Chan* ... Address: Department of ...
Cited by 13 - Related articles - View as HTML - All 14 versions

Gene-nutrient interactions during fetal development

- reproduction-online.org
CA Maloney, WD Rees - Reproduction, 2005 - Soc Reprod Fertility
Eukaryotic cells have evolved a complex series of nutrient sensors that protect
them from damage caused by acute deficiencies and also mediate adaptive
responses to prolonged excess or deficiency of particular nutrients. In ...
Cited by 12 - Related articles - BL Direct - All 6 versions

Peroxisome Proliferator-Activated Receptor (PPAR)-{alpha} Agonism Prevents the Onset of …

- endojournals.org
R Bergeron, J Yao, JW Woods, EI Zycband, C … - Endocrinology, 2006 - Endocrine Soc
Peroxisome proliferator-activated receptor (PPAR)- agonists are insulin
sensitizers, whereas PPAR agonists are lipid-lowering agents in humans. Chronic
treatment with PPAR agonists has been shown to prevent the onset of ...
Cited by 13 - Related articles - BL Direct - All 4 versions


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