P Pelegrin, A Surprenant - The EMBO journal, 2006 - pubmedcentral.nih.gov P2X 7 receptors are ATP-gated cation channels; their activation in macrophage
also leads to rapid opening of a membrane pore permeable to dyes such as
ethidium, and to release of the pro-inflammatory cytokine, interleukin-1β ... Cited by 215 - Related articles - BL Direct - All 5 versions
- ►nih.gov V Saks, P Dzeja, U Schlattner, M Vendelin, A … - The Journal of Physiology, 2006 - Physiological Soc The fundamental principle of cardiac behaviour is described by the
Frank-Starling law relating force of contraction during systole with
end-diastolic volume. While both work and respiration rates increase ... Cited by 80 - Related articles - BL Direct - All 8 versions
B Liss, O Haeckel, J Wildmann, T Miki, S … - Nature neuroscience, 2005 - uni-ulm.de The selective degeneration of dopaminergic (DA) midbrain neurons in the
substantia nigra (SN) is a hallmark of Parkinson disease. DA neurons in the
neighboring ventral tegmental area (VTA) are significantly less affected. ... Cited by 64 - Related articles - BL Direct - All 11 versions
- ►cell.com HC Towle - Trends in Endocrinology & Metabolism, 2005 - Elsevier Glucose has essential metabolic roles as both a fuel for energy and a substrate
for the biosynthesis of cell components. Because of its central importance, many
cells have evolved mechanisms to sense glucose levels in their environment ... Cited by 51 - Related articles - All 8 versions
F Chimienti, A Favier, M Seve - Biometals, 2005 - Springer The zinc content in the pancreatic beta cell is among the highest of the body.
Zinc appears to be an important metal for insulin-secreting cells as insulin is
stored inside secretory vesicles as a solid hexamer bound with two Zn 2+ ... Cited by 37 - Related articles - BL Direct - All 5 versions
- ►jbc.org YW Lin, C MacMullen, A Ganguly, CA Stanley … - Journal of Biological Chemistry, 2006 - ASBMB The -cell ATP-sensitive potassium (K ATP ) channel controls insulin secretion by
linking glucose metabolism to membrane excitability. Loss of K ATP channel
function due to mutations in ABCC8 or KCNJ11, genes that encode the ... Cited by 34 - Related articles - BL Direct - All 6 versions
MA Sperling - Current opinion in pediatrics, 2005 - journals.lww.com Recent findings: Recent reports in the literature, all in the past year, have
identified activating mutations in the K ATP channel that prevent its closure
and hence insulin secretion as the major cause of permanent neonatal ... Cited by 20 - Related articles - BL Direct - All 5 versions
- ►shouxi.net AI Tarasov, HJ Welters, S Senkel, GU Ryffel, … - Diabetes, 2006 - Am Diabetes Assoc ATP-sensitive K + channels (K ATP channels) couple ß-cell metabolism to
electrical activity and thereby play an essential role in the control of insulin
secretion. Gain-of-function mutations in Kir6.2 (KCNJ11), the pore-forming ... Cited by 17 - Related articles - BL Direct - All 5 versions
K Dezaki, M Kakei, T Yada - Diabetes, 2007 - Am Diabetes Assoc Ghrelin reportedly serves as a physiological regulator of insulin release. This
study aimed to explore signaling mechanisms for insulinostatic ghrelin action in
islet β-cells, with special attention to heterotrimeric GTP-binding ... Cited by 17 - Related articles - BL Direct - All 3 versions
- ►nih.gov CW Lin, F Yan, S Shimamura, S Barg, SL … - Diabetes, 2005 - Am Diabetes Assoc ATP-sensitive K + channels (K ATP channels) of pancreatic β-cells play key
roles in glucose-stimulated insulin secretion by linking metabolic signals to
cell excitability. Membrane phosphoinositides, in particular ... Cited by 16 - Related articles - BL Direct - All 6 versions
