- ►nih.gov FM Ashcroft - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig ATP-sensitive potassium (K ATP ) channels, so named because they are inhibited
by intracellular ATP , play key physiological roles in many tissues. In
pancreatic β cells, these channels regulate glucose-dependent insulin ... Cited by 142 - Related articles - BL Direct - All 14 versions
CG Nichols - Nature, 2006 - nature.com Even in the absence of ATP, the single-channel kinetics of K ATP are complex,
but certain key features are clearly discernible and can be modelled by assuming
a single 'fast' gate and ligand-operated 'slow' gates within each subunit ... Cited by 136 - Related articles - BL Direct - All 8 versions
AL Gloyn, J Siddiqui, S Ellard - Human mutation, 2006 - interscience.wiley.com The beta-cell ATP-sensitive potassium channel is a key component of
stimulus-secretion coupling in the pancreatic beta-cell. The channel couples
metabolism to membrane electrical events, bringing about insulin secretion. ... Cited by 32 - Related articles - BL Direct - All 3 versions
A Frelet, M Klein - FEBS letters, 2006 - Elsevier With regard to structure–function relations of ATP-binding cassette (ABC)
transporters several intriguing questions are in the spotlight of active
research: Why do functional ABC transporters possess two ATP binding and ... Cited by 29 - Related articles - All 7 versions
AM Patch, SE Flanagan, C Boustred, AT … - Diabetes Obes Metab, 2007 - interscience.wiley.com It is also possible that your web browser is not configured or not able to
display style sheets. In this case, although the visual presentation will be
degraded, the site should continue to be functional. We recommend using the ... Cited by 9 - Related articles - All 3 versions
- ►nih.gov H de Wet, MG Rees, K Shimomura, J … - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences Gain-of-function mutations in the genes encoding the ATP-sensitive potassium (K
ATP ) channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) are a common cause of
neonatal diabetes mellitus. Here we investigate the molecular mechanism by ... Cited by 9 - Related articles - BL Direct - All 7 versions
H de Wet, MV Mikhailov, C Fotinou, M Dreger, … - FEBS JOURNAL, 2007 - interscience.wiley.com The ATP-sensitive potassium (K ATP ) channel couples glucose metabolism to
insulin secretion in pancreatic β-cells. It comprises regulatory sulfonylurea
receptor 1 and pore-forming Kir6.2 subunits. Binding and/or hydrolysis of ... Cited by 9 - Related articles - BL Direct - All 4 versions
SE Flanagan, S Clauin, C Bellanné-Chantelot, … - Hum Mutat, 2009 - interscience.wiley.com The beta-cell ATP-sensitive potassium (K ATP ) channel is a key component of
stimulus-secretion coupling in the pancreatic beta-cell. The channel couples
metabolism to membrane electrical events bringing about insulin secretion. ... Cited by 4 - Related articles - All 3 versions