- ►nih.gov T Nir, DA Melton, Y Dor - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig The mechanisms that regulate pancreatic β cell mass are poorly understood. While autoimmune
and pharmacological destruction of insulin-producing β cells is often irreversible, adult β cell
mass does fluctuate in response to physiological cues including pregnancy and insulin ... Cited by 103 - Related articles - BL Direct - All 8 versions
MY Donath, JA Ehses, K Maedler, DM Schumann, H … - Diabetes, 2005 - Am Diabetes Assoc A decrease in the number of functional insulin-producing β-cells contributes to the pathophysiology
of type 2 diabetes. Opinions diverge regarding the relative contribution of a decrease in β-cell
mass versus an intrinsic defect in the secretory machinery. Here we review the evidence ... Cited by 86 - Related articles - BL Direct - All 6 versions
- ►endojournals.org A Wiederkehr, CB Wollheim - Endocrinology, 2006 - Endocrine Soc Mitochondria are essential for intermediary metabolism as well as energy production in the
cell. Their aerobic metabolism permits oxidation of glucose and fatty acids for the generation
of ATP and other intermediates that are exchanged with the cytoplasm for various ... Cited by 55 - Related articles - BL Direct - All 4 versions
P Marchetti, M Bugliani, R Lupi, L Marselli, M Masini, U … - Diabetologia, 2007 - Springer Page 1. ARTICLE The endoplasmic reticulum in pancreatic beta cells of type 2
diabetes patients P. Marchetti & M. Bugliani & R. Lupi & L. Marselli & M. Masini &
U. Boggi & F. Filipponi & GC Weir & DL Eizirik & M. Cnop Received ... Cited by 47 - Related articles - BL Direct - All 2 versions
- ►nih.gov BM Desai, J Oliver-Krasinski, DD De Leon, … - Journal of Clinical …, 2007 - Am Soc Clin Investig It has been suggested that pancreatic acinar cells can serve as progenitors for pancreatic
islets, a concept with substantial implications for therapeutic efforts to increase insulin-producing
β cell mass in patients with diabetes. We report what we believe to be the first in vivo ... Cited by 41 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org JA Emamaullee, AM Shapiro - Diabetes, 2006 - Am Diabetes Assoc A substantial proportion of the transplanted islet mass fails to engraft due to death by
apoptosis, and a number of strategies have been explored to inhibit β-cell loss. Inhibition of extrinsic
signals of apoptosis (ie, cFLIP or A20) have been explored in experimental islet ... Cited by 31 - Related articles - BL Direct - All 10 versions
AH Xiang, C Wang, RK Peters, E Trigo, SL Kjos, TA … - Diabetes, 2006 - Am Diabetes Assoc The purpose of this study was to examine longitudinally the relationship among glucose
levels, pancreatic β-cell function, and insulin resistance in women at high risk for type 2
diabetes. Oral glucose tolerance tests (OGTTs) and intravenous glucose tolerance tests ( ... Cited by 33 - Related articles - BL Direct - All 5 versions
- ►shouxi.net G Xu, H Kaneto, DR Laybutt, VF Duvivier-Kali, N Trivedi … - Diabetes, 2007 - Am Diabetes Assoc Stimulation of insulin secretion by the incretin hormones glucagon-like peptide 1 (GLP-1) and
glucose-dependent insulinotropic peptide (GIP) has been found to be diminished in type 2
diabetes. We hypothesized that this impairment is due to a defect at the receptor level ... Cited by 26 - Related articles - BL Direct - All 5 versions
KL Ong, LYF Wong, YB Man, RYH Leung, YQ Song, … - Peptides, 2006 - Elsevier We studied single nucleotide polymorphisms (SNPs) and haplotypes in the urotensin-II
(UTS2) and urotensin-II receptor gene (UTS2R) in Hong Kong Chinese (224 hypertensive and
306 normotensive unrelated subjects) and their relation to hypertension and the ... Cited by 23 - Related articles - All 5 versions
- ►diabetesjournals.org DJ Michael, RA Ritzel, L Haataja, RH Chow - Diabetes, 2006 - Am Diabetes Assoc Insulin vesicles contain a chemically rich mixture of cargo that includes ions, small
molecules, and proteins. At present, it is unclear if all components of this cargo escape from the
vesicle at the same rate or to the same extent during exocytosis. Here, we demonstrate ... Cited by 23 - Related articles - BL Direct - All 6 versions
