I Franklin, J Gromada, A Gjinovci, S Theander, CB … - Diabetes, 2005 - Am Diabetes Assoc Glucagon, secreted from islet α-cells, mobilizes liver glucose. During hyperglycemia, glucagon
secretion is inhibited by paracrine factors from other islet cells, but in type 1 and type 2 diabetic
patients, this suppression is lost. We investigated the effects of β-cell secretory products ... Cited by 74 - Related articles - All 4 versions
- ►diabetesjournals.org MA Ravier, GA Rutter - Diabetes, 2005 - Am Diabetes Assoc The mechanisms by which hypoglycemia stimulates glucagon release are still poorly
understood. In particular, the relative importance of direct metabolic coupling versus paracrine
regulation by β-cell secretory products is unresolved. Here, we compare the responses to ... Cited by 66 - Related articles - All 5 versions
- ►endojournals.org J Gromada, I Franklin, CB Wollheim - Endocrine reviews, 2007 - Endocrine Soc Glucagon, a hormone secreted from the -cells of the endocrine pancreas, is critical for blood
glucose homeostasis. It is the major counterpart to insulin and is released during hypoglycemia
to induce hepatic glucose output. The control of glucagon secretion is multifactorial and ... Cited by 61 - Related articles - BL Direct - All 4 versions
- ►endojournals.org HL Olsen, S Theander, K Bokvist, K Buschard, CB … - Endocrinology, 2005 - Endocrine Soc In isolated rat pancreatic -cells, glucose, arginine, and the sulfonylurea tolbutamide stimulated
glucagon release. The effect of glucose was abolished by the K ATP -channel opener diazoxide
as well as by mannoheptulose and azide, inhibitors of glycolysis and mitochondrial ... Cited by 43 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org PE MacDonald, S Obermüller, J Vikman, J … - Diabetes, 2005 - Am Diabetes Assoc We have applied cell-attached capacitance measurements to investigate whether synaptic-like
microvesicles (SLMVs) undergo regulated exocytosis in insulinoma and primary pancreatic
β-cells. SLMV and large dense-core vesicle (LDCV) exocytosis was increased 1.6- and ... Cited by 33 - Related articles - All 5 versions
PE MacDonald, YZ De Marinis, R Ramracheya, A … - PLoS Biol, 2007 - biology.plosjournals.org Glucagon, secreted from pancreatic islet α cells, stimulates gluconeogenesis and liver glycogen
breakdown. The mechanism regulating glucagon release is debated, and variously attributed
to neuronal control, paracrine control by neighbouring β cells, or to an intrinsic glucose ... Cited by 26 - Related articles - Cached - All 7 versions
A Salehi, E Vieira, E Gylfe - Diabetes, 2006 - Am Diabetes Assoc Hypersecretion of glucagon contributes to the dysregulation of glucose homeostasis in
diabetes. To clarify the underlying mechanism, glucose-regulated glucagon secretion was studied
in mouse pancreatic islets and clonal hamster In-R1-G9 glucagon-releasing cells. Apart ... Cited by 24 - Related articles - BL Direct - All 5 versions
E Vieira, A Salehi, E Gylfe - Diabetologia, 2007 - Springer Abstract Aims/hypothesis The mechanisms by which glucose regu- lates glucagon release are
poorly understood. The present study aimed to clarify the direct effects of glucose on the
glucagon-releasing alpha cells and those effects mediated by paracrine islet factors. ... Cited by 24 - Related articles - BL Direct - All 4 versions
K Hussain, J Bryan, HT Christesen, K Brusgaard, L … - Diabetes, 2005 - Am Diabetes Assoc The mechanisms involved in the release of glucagon in response to hypoglycemia are
unclear. Proposed mechanisms include the activation of the autonomic nervous system via
glucose-sensing neurons in the central nervous system, via the regulation of glucagon ... Cited by 22 - Related articles - BL Direct - All 7 versions
- ►endojournals.org YM Leung, I Ahmed, L Sheu, RG Tsushima, NE … - Endocrinology, 2005 - Endocrine Soc We recently reported a transgenic [mouse insulin promoter (MIP)-green fluorescent protein
(GFP)] mouse in which GFP expression is targeted to the pancreatic islet ß-cells to enable convenient
identification of ß-cells as green cells. The GFP-expressing ß-cells of the MIP-GFP mouse ... Cited by 21 - Related articles - BL Direct - All 4 versions
