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Scholar Results 1 - 10 of about 37 citing Henquin: Pathways in beta-cell stimulus-secretion coupling as targets for therapeutic insulin.... (0.11 sec) 

TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion


K Togashi, Y Hara, T Tominaga, T Higashi, Y … - The EMBO journal, 2006 - pubmedcentral.nih.gov
There are eight thermosensitive TRP (transient receptor potential) channels in
mammals, and there might be other TRP channels sensitive to temperature stimuli.
Here, we demonstrate that TRPM2 can be activated by exposure to warm ...
Cited by 70 - Related articles - BL Direct - All 10 versions

Minireview: implication of mitochondria in insulin secretion and action

- endojournals.org
A Wiederkehr, CB Wollheim - Endocrinology, 2006 - Endocrine Soc
Mitochondria are essential for intermediary metabolism as well as energy
production in the cell. Their aerobic metabolism permits oxidation of glucose
and fatty acids for the generation of ATP and other intermediates that are ...
Cited by 53 - Related articles - BL Direct - All 4 versions

A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase …


SM Ronnebaum, O Ilkayeva, SC Burgess, JW … - Journal of Biological Chemistry, 2006 - ASBMB
Glucose-stimulated insulin secretion (GSIS) from pancreatic islet β-cells is
central to control of mammalian fuel homeostasis. Glucose metabolism mediates
GSIS in part via ATP-regulated K + (K ATP ) channels, but multiple lines of ...
Cited by 41 - Related articles - All 5 versions

ABCC8 and ABCC9: ABC transporters that regulate K+ channels

- pubget.com [PDF] 
J Bryan, A Muñoz, X Zhang, M Düfer, G Drews … - Pflügers Archiv European Journal of Physiology, 2007 - Springer
Abstract The sulfonylurea receptors (SURs) ABCC8/ SUR1 and ABCC9/SUR2 are
members of the C-branch of the transport adenosine triphosphatase superfamily.
Unlike their brethren, the SURs have no identified transport function; ...
Cited by 31 - Related articles - BL Direct - All 6 versions

The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated …


JW Joseph, MV Jensen, O Ilkayeva, F … - Journal of Biological Chemistry, 2006 - ASBMB
Glucose-stimulated insulin secretion (GSIS) is mediated in part by glucose
metabolism-driven increases in ATP/ADP ratio, but by-products of mitochondrial
glucose metabolism also play an important role. Here we investigate the ...
Cited by 28 - Related articles - All 7 versions

β-Cell Mitochondria exhibit membrane potential heterogeneity that can be altered by …

- diabetesjournals.org
JD Wikstrom, SM Katzman, H Mohamed, G Twig, … - Diabetes, 2007 - Am Diabetes Assoc
OBJECTIVE—β-Cell response to glucose is characterized by mitochondrial
membrane potential (ΔΨ) hyperpolarization and the production of metabolites
that serve as insulin secretory signals. We have previously shown that ...
Cited by 11 - Related articles - BL Direct - All 3 versions

Glibenclamide-induced apoptosis is specifically enhanced by expression of the …

- aspetjournals.org
A Hambrock, CB de Oliveira Franz, S Hiller, … - Journal of Pharmacology and Experimental …, 2006 - ASPET
Sulfonylurea receptor 1 (SUR1) is the regulatory subunit of the pancreatic
ATP-sensitive K + channel (K ATP channel), which is essential for triggering
insulin secretion via membrane depolarization. Sulfonylureas, such as ...
Cited by 10 - Related articles - BL Direct - All 5 versions

Interactive influences of peroxisome proliferator-activated receptor α activation and …


MJ Holness, ND Smith, GK Greenwood, MC … - Diabetologia, 2005 - Springer
Abstract Aims/hypothesis: We sought to elucidate whether excess glucocorticoids
and increased dietary lip- ids act synergistically to impair glucose tolerance
and, if so, whether activation of peroxisome proliferator-activated ...
Cited by 9 - Related articles - BL Direct - All 4 versions

Diabetes in very young children and mutations in the insulin-secreting cell potassium …


I Flechtner, M Vaxillaire, H Cav├®, R … - Endocrine development, 2007 - content.karger.com
Shield JPH, Scharfmann R (eds): Development of the Pancreas and Neonatal
Diabetes. Endocr Dev. Basel, Karger, 2007, vol 12, pp 86–98 ... Abstract
ATP-sensitive potassium (K ATP ) channels regulate the flux of K + ions ...
Cited by 8 - Related articles - BL Direct - All 4 versions

Role of nuclear receptors in the modulation of insulin secretion in lipid-induced insulin …


M Sugden, M Holness - Biochemical Society Transactions, 2008 - biochemsoctrans.org
Abbreviations used: ACL, ATP citrate-lyase; ERK, extracellular-signal-regulated
kinase; FA, fatty acid; FFAR1, free FA receptor 1; GC, glucocorticoid; GK,
glucokinase; GLUT2, glucose transporter 2; GPCR, G-protein-coupled ...
Cited by 7 - Related articles - Cached - All 6 versions


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