- ►nih.gov N Zelcer, P Tontonoz - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig The liver X receptors (LXRs) are nuclear receptors that play central roles in
the transcriptional control of lipid metabolism. LXRs function as nuclear
cholesterol sensors that are activated in response to elevated ... Cited by 211 - Related articles - BL Direct - All 11 versions
- ►endojournals.org AM Efanov, DG Barrett, MB Brenner, SL Briggs … - Endocrinology, 2005 - Endocrine Soc The glucose-sensing enzyme glucokinase (GK) plays a key role in glucose
metabolism. We report here the effects of a novel glucokinase activator,
LY2121260. The activator enhanced GK activity via binding to the allosteric ... Cited by 55 - Related articles - BL Direct - All 5 versions
W Wente, AM Efanov, M Brenner, A … - Diabetes, 2006 - Am Diabetes Assoc Fibroblast growth factor-21 (FGF-21) is a recently discovered metabolic
regulator. Here, we investigated the effects of FGF-21 in the pancreatic
β-cell. In rat islets and INS-1E cells, FGF-21 activated extracellular ... Cited by 56 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org JC Henquin - Diabetes, 2004 - Am Diabetes Assoc Physiologically, insulin secretion is subject to a dual, hierarchal control by
triggering and amplifying pathways. By closing ATP-sensitive K + channels (K ATP
channels) in the plasma membrane, glucose and other metabolized nutrients ... Cited by 37 - Related articles - BL Direct - All 4 versions
- ►endojournals.org H Zitzer, W Wente, MB Brenner, S Sewing, K … - Endocrinology, 2006 - Endocrine Soc Liver X receptors (LXR and LXRß) regulate glucose and lipid metabolism.
Pancreatic ß-cells and INS-1E insulinoma cells express only the LXRß isoform.
Activation of LXRß with the synthetic agonist T0901317 increased glucose- ... Cited by 23 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org SS Choe, AH Choi, JW Lee, KH Kim, JJ Chung, … - Diabetes, 2007 - Am Diabetes Assoc Liver X receptor (LXR)α and LXRβ play important roles in fatty acid metabolism
and cholesterol homeostasis. Although the functional roles of LXR in the liver,
intestine, fat, and macrophages are well established, its role in ... Cited by 23 - Related articles - BL Direct - All 6 versions
- ►endojournals.org W Wente, MB Brenner, H Zitzer, J Gromada, … - Endocrinology, 2007 - Endocrine Soc Liver X receptors (LXRs) form functional heterodimers with the retinoid X
receptors (RXRs) and regulate cholesterol, lipid, and glucose metabolism. We
demonstrated previously that activation of LXR modulates insulin secretion ... Cited by 22 - Related articles - BL Direct - All 3 versions
S Fernandez-Veledo, I Nieto-Vazquez, CM … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis The nuclear receptors, including nuclear receptor
subfamily 1, group H, member 3 (NR1HR, also known as liver X receptor [LXR]),
are sensors of cholesterol metabolism and lipid biosynthesis that have ... Cited by 17 - Related articles - All 4 versions
- ►aspetjournals.org M Loffler, M Bilban, M Reimers, W Waldhausl, … - Journal of Pharmacology and Experimental …, 2006 - ASPET Agonists of the nuclear receptors peroxisome proliferator-activated receptor
(PPAR) , PPAR , and liver X receptors (LXRs) reduce blood glucose in type 2
diabetic patients and comparable mouse models. Since the capacity of these ... Cited by 16 - Related articles - BL Direct - All 5 versions
- ►endojournals.org SR Commerford, L Vargas, SE Dorfman, N … - Molecular Endocrinology, 2007 - Endocrine Soc The liver X receptors (LXR and β) are nuclear receptors that coordinate
carbohydrate and lipid metabolism. Treatment of insulin-resistant mice with
synthetic LXR ligands enhances glucose tolerance, inducing changes in gene ... Cited by 15 - Related articles - BL Direct - All 3 versions
