P Ferre, F Foufelle - Horm Res, 2007 - content.karger.com Insulin has long-term effects on glucose and lipid metabolism through its control on the expression
of specific genes. In insulin sensitive tissues and particularly in the liver, the transcription factor
sterol regulatory element binding protein-1c (SREBP-1c) transduces the insulin signal. ... Cited by 39 - Related articles - BL Direct - All 5 versions
I Leclerc, GA Rutter - Diabetes, 2004 - Am Diabetes Assoc Stimulation of AMP-activated protein kinase (AMPK) in skeletal muscle and liver is seen as an
exciting prospect for the treatment of type 2 diabetes. However, we have recently demonstrated
that changes in AMPK activity accompany the exposure of pancreatic islet β-cells to ... Cited by 28 - Related articles - BL Direct - All 5 versions
- ►endocrinology-journals.org K Ravnskjaer, M Boergesen, LT Dalgaard, S … - Journal of molecular …, 2006 - Soc Endocrinology Tight regulation of fatty acid metabolism in pancreatic ß-cells is important for ß-cell viability and
function. Chronic exposure to elevated concentrations of fatty acid is associated with ß-cell
lipotoxicity. Glucose is known to repress fatty acid oxidation and hence to augment the ... Cited by 24 - Related articles - BL Direct - All 4 versions
… , SL Macaulay, MA Febbraio, BE Kemp - Canadian journal of …, 2006 - article.pubs.nrc-cnrc.gc.ca Abstract: AMP-activated protein kinase plays an important role in the regulation of lipid metabolism
in response to meta- bolic stress and energy demand. It is also under endocrine control. AMPK
acts at multiple steps and has a central role controlling fatty acid, triglyceride, and ... Cited by 18 - Related articles - BL Direct - All 6 versions
X Wang, L Zhou, G Li, T Luo, Y Gu, L Qian, X Fu, F … - … and Biophysical Research …, 2007 - Elsevier AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular
metabolism. Changes in AMPK activity contribute to the regulation of insulin secretion. Epidemiological
evidence links the ingestion of saturated fatty acid with hyperinsulinemia. The aim of the ... Cited by 13 - Related articles - All 4 versions
HK Nyblom, LI Nord, R Andersson, L Kenne, … - NMR in …, 2008 - interscience.wiley.com Raised concentrations of glucose for extended periods of time have detrimental effects on the
insulin-producing -cell. As de novo synthesis of lipids has been observed under such
conditions, it was hypothesized that newly formed lipids may preferentially contain ... Cited by 4 - Related articles - BL Direct - All 2 versions
- ►endojournals.org L Zhou, X Wang, L Shao, Y Yang, W Shang, G Yuan, B … - Endocrinology, 2008 - Endocrine Soc Berberine, a hypoglycemic agent, has recently been shown to activate AMP-activated protein
kinase (AMPK) contributing to its beneficial metabolic effects in peripheral tissues. However,
whether berberine exerts a regulatory effect on β-cells via AMPK or other signaling ... Cited by 4 - Related articles - All 2 versions
- ►jlr.org F Diraison, MA Ravier, SK Richards, RM Smith, H … - The Journal of Lipid …, 2008 - ASBMB Previous studies have reported both positive and negative effects of culture of islets at high glucose
concentrations on regulated insulin secretion. Here, we have reexamined this question in mouse
islets and determined the role of changes in lipid synthesis in the effects of glucose. ... Cited by 4 - Related articles - All 5 versions
JW Kim, JH Cho, SH Ko, H Park, J Ha, KH Song, … - … and biophysical research …, 2007 - Elsevier It is well known that the activation of AMP-activated protein kinase (AMPK) represses insulin
gene expression and glucose-stimulated insulin secretion. However, how this effect is achieved
and the effects of AMPK activation on glucolipotoxicity-induced β-cell dysfunction have ... Cited by 3 - Related articles - All 5 versions
SW Kim, HJ Hwang, YM Baek, SH Lee, HS Hwang, JW … - Proteomics, 2008 - kcms.daegu.ac.kr In an attempt to search for novel biomarkers for monitoring diabetes prognosis, we examined
the influence of the hypoglycemic fungal extracellular polysaccharides (EPS) on the differential
change in pancreatic proteome and transcriptome in streptozotocin (STZ)-induced ... Cited by 2 - Related articles - View as HTML - All 6 versions
