- ►diabetesjournals.org M Cnop, N Welsh, JC Jonas, A Jörns, S Lenzen … - Diabetes, 2005 - Am Diabetes Assoc Type 1 and type 2 diabetes are characterized by progressive β-cell failure.
Apoptosis is probably the main form of β-cell death in both forms of the
disease. It has been suggested that the mechanisms leading to nutrient- and ... Cited by 171 - Related articles - BL Direct - All 10 versions
- ►physiology.org SF Liu, AB Malik - American Journal of Physiology- Lung Cellular and …, 2006 - Am Physiological Soc The pathophysiology of sepsis and septic shock involves complex cytokine and
inflammatory mediator networks. NF- B activation is a central event leading to
the activation of these networks. The role of NF- B in septic ... Cited by 135 - Related articles - BL Direct - All 3 versions
- ►shouxi.net MY Donath, JA Ehses, K Maedler, DM … - Diabetes, 2005 - Am Diabetes Assoc A decrease in the number of functional insulin-producing β-cells contributes to
the pathophysiology of type 2 diabetes. Opinions diverge regarding the relative
contribution of a decrease in β-cell mass versus an intrinsic defect in ... Cited by 85 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org S Papadopoulou, H Edlund - Diabetes, 2005 - Am Diabetes Assoc Mesenchymal-epithelial interactions are pivotal for proper pancreatic growth and
development. We have earlier shown that the fibroblast growth factor (FGF)
receptor 2 is expressed in pancreatic progenitor cells and that FGF10, the ... Cited by 57 - Related articles - BL Direct - All 6 versions
S Gerondakis, R Grumont, R Gugasyan, L … - Oncogene, 2006 - nature.com The nuclear factor- B (NF- B) signalling pathway serves a crucial role in
regulating the transcriptional responses of physiological processes that include
cell division, cell survival, differentiation, immunity and inflammation. ... Cited by 52 - Related articles - BL Direct - All 5 versions
- ►nih.gov R Eldor, A Yeffet, K Baum, V Doviner, D Amar, … - Proceedings of the National Academy of Sciences, 2006 - National Acad Sciences Type 1 diabetes is characterized by the infiltration of inflammatory cells into
pancreatic islets of Langerhans, followed by the selective and progressive
destruction of insulin-secreting beta cells. Islet-infiltrating leukocytes ... Cited by 50 - Related articles - BL Direct - All 8 versions
- ►jbc.org EB Hammar, JC Irminger, K Rickenbach, G … - Journal of Biological Chemistry, 2005 - ASBMB Laminin-5-rich extracellular matrix derived from 804G cells (804G-ECM) engages 1
integrins to induce spreading, improve glucose-stimulated insulin secretion
(GSIS), and increase survival of pancreatic beta cells. The present study ... Cited by 39 - Related articles - BL Direct - All 5 versions
M Pasparakis, T Luedde, M Schmidt-Supprian - Cell Death & Differentiation, 2006 - nature.com Studies in transgenic and knockout mice have made a major contribution to our
current understanding of the physiological functions of the NF- B signalling
cascade. The generation and analysis of mice with targeted modifications of ... Cited by 39 - Related articles - BL Direct - All 4 versions
- ►pnas.org S Kim, I Millet, HS Kim, JY Kim, MS Han, MK … - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences Whereas NF-κB has potent antiapoptotic function in most cell types, it was
reported that in pancreatic β cells it serves a proapoptotic function and may
contribute to the pathogenesis of autoimmune type 1 diabetes. To ... Cited by 31 - Related articles - BL Direct - All 10 versions
N Produit-Zengaffinen, N Davis-Lameloise, H … - Diabetologia, 2007 - Springer Page 1. ARTICLE Increasing uncoupling protein-2 in pancreatic beta cells does
not alter glucose-induced insulin secretion but decreases ... Cited by 26 - Related articles - BL Direct - All 4 versions
