- ►rh.dk [PDF] LL Baggio, DJ Drucker - Gastroenterology, 2007 - Elsevier This review focuses on the mechanisms regulating the synthesis, secretion, biological
actions, and therapeutic relevance of the incretin peptides glucose-dependent insulinotropic
polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). The published literature was ... Cited by 179 - Related articles - All 25 versions
- ►medicaltherapies.com.au [PDF] DM Yellon, DJ Hausenloy - The New England journal of medicine, 2007 - nejm.highwire.org C oronary heart disease is the leading cause of death world- wide, and 3.8 million men and 3.4
million women die of the disease each year. After an acute myocardial infarction, early and successful
myocardial reperfusion with the use of thrombolytic therapy or primary percutaneous ... Cited by 178 - Related articles - BL Direct - All 5 versions
- ►physiology.org JJ Holst - Physiological reviews, 2007 - Am Physiological Soc Glucagon-like peptide 1 (GLP-1) is a 30-amino acid peptide hormone produced in the intestinal
epithelial endocrine L-cells by differential processing of proglucagon, the gene which is expressed
in these cells. The current knowledge regarding regulation of proglucagon gene ... Cited by 119 - Related articles - BL Direct - All 5 versions
MC Riddle, DJ Drucker - Diabetes Care, 2006 - Am Diabetes Assoc Current therapies for type 2 diabetes are frequently associated with inadequate control of postprandial
hyperglycemia, weight gain, and, in the case of oral agents, loss of efficacy over time. A better
understanding of physiological responses to meals is leading to the development of new ... Cited by 72 - Related articles - BL Direct - All 10 versions
GG Sokos, LA Nikolaidis, S Mankad, D Elahi, RP … - Journal of cardiac failure, 2006 - Elsevier We investigated the safety and efficacy of a 5-week infusion of GLP-1 (2.5 pmol/kg/min) added
to standard therapy in 12 patients with New York Heart Association class III/IV heart failure and
compared the results with those of 9 patients with heart failure on standard therapy alone. ... Cited by 62 - Related articles - All 12 versions
DJ Drucker - Nature Clinical Practice Endocrinology and Metabolism, 2005 - glucagon.com INTRODUCTION Before the cDNAs and genes encoding pro glucagon were cloned, pancreatic
glucagon was the prin- cipal proglucagon-derived peptide (PGDP) with well-characterized biologic
actions. However, antisera directed against glucagon detected not only circulating ... Cited by 60 - Related articles - View as HTML - BL Direct - All 6 versions
JJ Holst, CF Deacon - Current Opinion in Pharmacology, 2004 - Elsevier Glucagon-like peptide 1 (GLP-1) is a 30 amino acid peptide secreted by intestinal L-cells in response
to meal ingestion. It functions as one of the incretin hormones; that is, the gut hormones that enhance
nutrient-stimulated insulin secretion more than the nutrients themselves, if given ... Cited by 57 - Related articles - All 2 versions
DJ Hausenloy, DM Yellon - Heart failure reviews, 2007 - Springer Abstract Following an acute myocardial infarction (AMI), early coronary artery reperfusion remains
the most effective means of limiting the eventual infarct size. The resultant left ventricular systolic
function is a critical determinant of the patient's clinical outcome. Despite current ... Cited by 60 - Related articles - BL Direct - All 4 versions
DM Yellon, DJ Hausenloy - Nature clinical practice. Cardiovascular …, 2005 - ncbi.nlm.nih.gov After an acute myocardial infarction (AMI), early reperfusion by thrombolysis or primary percutaneous
coronary intervention remains the most-effective strategy for limiting the size of an evolving
infarct. The mortality from AMI, however, remains significant, due partly to the lethal ... Cited by 52 - Related articles - All 3 versions
CCT Smith, MM Mocanu, SM Davidson, … - British Journal of …, 2006 - pubmedcentral.nih.gov Key results: Leptin (10 nM) administered during reperfusion reduced infarct size
significantly. Protection was blocked by either LY294002 or UO126, inhibitors of Akt and
p44/42 MAPK, respectively. Western blotting confirmed that leptin stimulated p44/42 ... Cited by 42 - Related articles - BL Direct - All 3 versions
