- ►cell.com V De Rosa, C Procaccini, G Calì, G Pirozzi, S Fontana, … - Immunity, 2007 - Elsevier We report here that leptin can act as a negative signal for the proliferation of human naturally
occurring Foxp3 + CD4 + CD25 + regulatory T (T reg ) cells. Freshly isolated T reg cells produced
leptin and expressed high amounts ... Cited by 68 - Related articles - All 7 versions
ME Falagas, M Kompoti - The Lancet Infectious Diseases, 2006 - Elsevier Obesity increases morbidity and mortality through its multiple effects on nearly every human system.
However, the various aspects of the association between obesity and infection have not been
reviewed. Thus, we reviewed the ... Cited by 51 - Related articles - All 18 versions
QL Lam, S Liu, X Cao, L Lu - European journal of immunology, 2006 - interscience.wiley.com Previous studies demonstrated that lymphocyte development is impaired in leptin receptor
(Ob-R)-deficient db/db mice. However, it remains unclear whether or not leptin signaling plays a
physiological role in dendritic ... Cited by 21 - Related articles - BL Direct - All 4 versions
- ►nutrition.org AG Smith, PA Sheridan, JB Harp, MA Beck - Journal of Nutrition, 2007 - Am Soc Nutrition Obesity is associated with an impaired immune response, an increased susceptibility to bacterial
infection, and a chronic increase in proinflammatory cytokines such as IL-6 and TNF . However, few
studies have examined the effect of ... Cited by 21 - Related articles - BL Direct - All 5 versions
G Lord - Contributions to nephrology, 2006 - content.karger.com Abstract Leptin is a 16-kDa protein produced mainly by adipocytes. Animal models demonstrate that
leptin is required for control of bodyweight and reproduction, since mice defective in leptin or the
leptin receptor are obese, ... Cited by 17 - Related articles - BL Direct - All 5 versions
- ►jimmunol.org L Macia, M Delacre, G Abboud, TS Ouk, A … - The Journal of …, 2006 - Am Assoc Immnol There is a finely tuned interplay between immune and neuroendocrine systems. Metabolic disturbances
like obesity will have serious consequences on immunity both at the cellular and at the cytokine
expression levels. Our in vivo ... Cited by 17 - Related articles - BL Direct - All 5 versions
S Amar, Q Zhou, Y Shaik- … - Proceedings of the …, 2007 - National Acad Sciences Obesity has been suggested to be associated with an increased susceptibility to bacterial infection.
However, few studies have examined the effect of obesity on the immune response to bacterial
infections. In the present study, ... Cited by 19 - Related articles - BL Direct - All 8 versions
I Wolowczuk, C Verwaerde, O Viltart, A … - Clinical and …, 2008 - pubmedcentral.nih.gov Endogenous intestinal microflora and environmental factors, such as diet, play a central role in
immune homeostasis and reactivity. In addition, microflora and diet both influence body weight and
insulin-resistance, notably through ... Cited by 17 - Related articles - All 5 versions
L Fontana, JC Eagon, M Colonna, S Klein - Rejuvenation research, 2007 - liebertonline.com Background: Obesity is associated with an increased prevalence and severity of infections. The
mechanism(s) responsible for the increased risk of infections is unclear. We evaluated the effects
of excessive adiposity and weight ... Cited by 14 - Related articles - BL Direct - All 4 versions
H Sashinami, K Kageyama, T Suda, A Nakane - Endocrinology, 2005 - Endocrine Soc Previous studies have showed that corticotropin-releasing factor (CRF) modulates immune response
during inflammation. We investigated the effect of CRF family peptides on host resistance to
Listeria monocytogenes infection in ... Cited by 12 - Related articles - BL Direct - All 8 versions
