- ►aspetjournals.org P Pacher, A Nivorozhkin, C Szabo - Pharmacological reviews, 2006 - ASPET The prototypical xanthine oxidase (XO) inhibitor allopurinol, has been the
cornerstone of the clinical management of gout and conditions associated with
hyperuricemia for several decades. More recent data indicate that XO also ... Cited by 91 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org AKH Cheung, MKL Fung, ACY Lo, TTL Lam, … - Diabetes, 2005 - Am Diabetes Assoc In 15-month-old db/db mice, signs of diabetic retinopathy, including
blood-retinal barrier breakdown, loss of pericytes, neuro-retinal apoptosis,
glial reactivation, and proliferation of blood vessels, were evident. These ... Cited by 50 - Related articles - BL Direct - All 5 versions
- ►nih.gov P Pacher, C Szabó - Current opinion in pharmacology, 2006 - Elsevier Hyperglycemic episodes, which complicate even well-controlled cases of diabetes,
lead to increased polyol pathway flux, activation of protein kinase C and
accelerated non-enzymatic formation of advanced glycation end products. ... Cited by 43 - Related articles - All 5 versions
- ►diabetesjournals.org W Sun, PJ Oates, JB Coutcher, C … - Diabetes, 2006 - Am Diabetes Assoc Previously studied inhibitors of aldose reductase were largely from two chemical
classes, spirosuccinamide/hydantoins and carboxylic acids. Each class has its
own drawbacks regarding selectivity, in vivo potency, and human safety; as ... Cited by 38 - Related articles - BL Direct - All 7 versions
- ►nih.gov P Pacher, C Szabó - Antioxidants & redox signaling, 2005 - liebertonline.com Hyperglycemia-induced overproduction of superoxide by mitochondrial
electron-transport chain triggers several pathways of injury involved in the
pathogenesis of diabetic complications [protein kinase C (PKC), hexosamine ... Cited by 38 - Related articles - BL Direct - All 6 versions
- ►nih.gov IG Obrosova, VR Drel, P Pacher, O Ilnytska, … - Diabetes, 2005 - Am Diabetes Assoc Poly(ADP-ribose) polymerase (PARP) activation, an important factor in the
pathogenesis of diabetes complications, is considered a downstream effector of
oxidative-nitrosative stress. However, some recent findings suggest that it ... Cited by 37 - Related articles - BL Direct - All 11 versions
- ►nih.gov VR Drel, P Pacher, MJ Stevens, IG Obrosova - Free Radical Biology and Medicine, 2006 - Elsevier Both increased aldose reductase (AR) activity and oxidative/nitrosative stress
have been implicated in the pathogenesis of diabetic nephropathy, but the
relation between the two factors remains a subject of debate. This study ... Cited by 34 - Related articles - All 6 versions
- ►diabetesjournals.org VR Drel, N Mashtalir, O Ilnytska, J Shin, F Li … - Diabetes, 2006 - Am Diabetes Assoc Whereas functional, metabolic, neurotrophic, and morphological abnormalities of
peripheral diabetic neuropathy (PDN) have been extensively explored in
streptozotocin-induced diabetic rats and mice (models of type 1 diabetes), ... Cited by 31 - Related articles - BL Direct - All 7 versions
IG Obrosova - Antioxidants & Redox Signaling, 2005 - liebertonline.com T HE SORBITOL PATHWAY OF GLUCOSE METABOLISM consists of two reactions. First,
glucose is reduced to its sugar al- cohol sorbitol by NADPH-dependent aldose
reductase (AR), and then sorbitol is oxidized to fructose by NAD-dependent ... Cited by 30 - Related articles - BL Direct - All 4 versions
- ►nih.gov O Ilnytska, VV Lyzogubov, MJ Stevens, VR … - Diabetes, 2006 - Am Diabetes Assoc Poly(ADP-ribose) polymerase (PARP) activation is emerging as a fundamental
mechanism in the pathogenesis of diabetes complications including diabetic
neuropathy. This study evaluated the role of PARP in diabetic sensory ... Cited by 26 - Related articles - BL Direct - All 10 versions
