GM Subramanian, M Fiscella, A Lamousé-Smith, S … - Nature biotechnology, 2007 - nature.com Treatment regimens based on the use of interferon- (IFN- ) remain the cornerstone of therapy
for chronic hepatitis C virus infection, which affects nearly 170 million people worldwide. Treatment
options include unmodified IFN- given three times weekly or pegylated IFNs given once ... Cited by 25 - Related articles - BL Direct - All 4 versions
D Müller, A Karle, B Meissburger, I Höfig, R Stork, … - Journal of Biological …, 2007 - ASBMB Recombinant bispecific antibodies such as tandem scFv molecules (taFv), diabodies (Db), or
single chain diabodies (scDb) have shown to be able to retarget T lymphocytes to tumor
cells, leading to their destruction. However, therapeutic efficacy is hampered by a short ... Cited by 26 - Related articles - All 6 versions
S Brimijoin, Y Gao, JJ Anker, LA Gliddon, … - … official publication of …, 2008 - pubmedcentral.nih.gov Successive rational mutations of human butyrylcholinesterase (BChE) followed by fusion to human
serum albumin have yielded an efficient hydrolase that offers realistic options for therapy of cocaine
overdose and abuse. This albumin-BChE prevented seizures in rats given a normally ... Cited by 9 - Related articles - All 4 versions
C Girish, S Manikandan, M Jayanthi - Indian Journal of Medical Sciences, 2006 - Medknow Diabetes is a metabolic disease with high prevalence worldwide. Exogenous insulin is used
in the management of this condition. The development of human insulin has provided tighter
control of glycaemia in diabetic patients. Insulin analogues like insulin lispro and aspart ... Cited by 8 - Related articles - Cached - All 6 versions
T Weimer, W Wormsbächer, U Kronthaler, W … - Thrombosis and …, 2008 - ncbi.nlm.nih.gov For the treatment of haemophilia patients with inhibitors, recombinant factor VIIa (rFVIIa) is available
as a therapeutic option to control bleeding episodes with a good balance of safety and
efficacy. However, the short in-vivo half-life of approximately 2.5 hours makes multiple ... Cited by 7 - Related articles - BL Direct - All 3 versions
YS Huang, Z Chen, YQ Chen, GC Ma, JF … - Journal of Peptide …, 2008 - interscience.wiley.com A novel recombinant exendin-4 human serum albumin fusion protein (rEx-4/HSA) expressed
in Pichia pastoris was prepared and characterized. Ex-4 is a 39-amino acid peptide isolated
from the salivary gland of the lizard Heloderma suspectum and is thought to be a novel ... Cited by 7 - Related articles - BL Direct - All 3 versions
D Lillicrap - Thrombosis Research, 2008 - Elsevier The human coagulation factor VIII (FVIII) and von Willebrand factor (VWF) are two distinct glycoproteins
that circulate in the plasma as a non-covalently bound complex (VWF/FVIII complex). Deficiencies
or structural defects in FVIII and VWF are responsible for the most common inherited ... Cited by 2 - Related articles - All 5 versions
DL Lee, I Sharif, S Kodihalli, DIH Stewart, V … - Journal of Interferon & …, 2008 - liebertonline.com Conjugates of recombinant human granulocyte-macrophage colony-stimulating factor
(GM-CSF) attached to polyethylene glycol (PEG) chains were prepared using amine-reactive
chemistry. Molecular masses of the PEGs were 20, 30, and 40 kDa. The monopegylated ... Cited by 1 - Related articles - BL Direct - All 4 versions
CH Chang, P Gupta, DM … - Expert Opinion on Drug …, 2009 - informahealthcare.com Background: Recombinant forms of natural proteins with therapeutic potential rarely make ideal
pharmaceuticals. Fusion of these proteins to human serum albumin, human transferrin, the constant
region fragment of a human IgG or a desirable antibody to improve their bioavailability, ... Cited by 1 - Related articles - All 5 versions
G Rajpal, M Liu, Y Zhang, P Arvan - Molecular Endocrinology, 2009 - Endocrine Soc Single-chain insulins (SCIs) are single polypeptide chains in which the insulin B-chain links contiguously
with the insulin A-chain via an uncleaved connecting peptide. Although direct linkage of insulin
B- and A-chains produces SCIs with little insulin receptor binding, biologists have been ... Related articles - All 4 versions
