- ►ahajournals.org SM Grundy, JI Cleeman, SR Daniels, KA … - Circulation, 2005 - Am Heart Assoc The metabolic syndrome is a constellation of interrelated risk factors of
metabolic origin—metabolic risk factors—that appear to directly promote the
development of atherosclerotic cardiovascular disease (ASCVD). 1 Patients ... Cited by 2047 - Related articles - BL Direct - All 11 versions
- ►shouxi.net J Munoz, KH Lok, BA Gower, JR Fernandez, … - Diabetes, 2006 - Am Diabetes Assoc Recently, the transcription factor 7-like 2 (TCF7L2) gene on chromosome 10q25.2
has been linked with type 2 diabetes among Caucasians, with disease associations
noted for single nucleotide polymorphisms (SNPs) rs12255372 and rs7903146. ... Cited by 53 - Related articles - BL Direct - All 5 versions
H Parikh, E Carlsson, WA Chutkow, LE … - PLoS Med, 2007 - medicine.plosjournals.org We combined human insulin/glucose clamp physiological studies with genome-wide
expression profiling to identify thioredoxin interacting protein (TXNIP) as a
gene whose expression is powerfully suppressed by insulin yet stimulated by ... Cited by 35 - Related articles - Cached - All 15 versions
- ►endojournals.org SM Clee, AD Attie - Endocrine reviews, 2007 - Endocrine Soc Inbred mouse strains provide genetic diversity comparable to that of the human
population. Like humans, mice have a wide range of diabetes-related phenotypes.
The inbred mouse strains differ in the response of their critical ... Cited by 28 - Related articles - BL Direct - All 4 versions
- ►shouxi.net P Poulsen, A Vaag - Diabetes, 2006 - Am Diabetes Assoc According to the “fetal origins hypothesis,” monozygotic (MZ) twins may be
more prone to develop various metabolic abnormalities compared with dizygotic
(DZ) twins, and twins all together may be more predisposed to metabolic ... Cited by 25 - Related articles - BL Direct - All 5 versions
- ►shouxi.net E Carlsson, P Poulsen, H Storgaard, P … - Diabetes, 2005 - Am Diabetes Assoc The gene encoding calpain-10 (CAPN10) has been identified as a candidate gene
for type 2 diabetes. Our aim was to study the impact of genetic (heritability
and polymorphisms) and nongenetic (insulin, free fatty acids, and age) ... Cited by 21 - Related articles - BL Direct - All 5 versions
- ►shouxi.net RN Bergman - Diabetes, 2007 - Am Diabetes Assoc Type 2 diabetes is increasing at alarming rates in the US, in Westernized
countries, and in the third world. The increasing costs in terms of human
suffering as well as economics are well recognized (1). Improved ... Cited by 16 - Related articles - BL Direct - All 9 versions
- ►endojournals.org N Rasouli, T Hale, SE Kahn, HJ Spencer, SC … - Journal of Clinical Endocrinology & Metabolism, 2005 - Endocrine Soc Context: Normal glucose homeostasis is maintained despite reductions in insulin
sensitivity by increasing insulin secretion. This ability to compensate for
reduced insulin sensitivity is highly heritable, but the mechanisms for ... Cited by 14 - Related articles - BL Direct - All 5 versions
MA Karim, X Wang, TC Hale, SC Elbein - BMC Medical Genetics, 2005 - biomedcentral.com We identified 8 variants in the two populations, including a 3 bp insertion in
exon 2 (InsCCG243) in African Americans that resulted in an in-frame proline
insertion in the transactivation domain. No variant was associated with ... Cited by 12 - Related articles - Cached - All 8 versions
- ►endojournals.org L Wegner, MS Hussain, K Pilgaard, T Hansen … - Journal of Clinical Endocrinology & Metabolism, 2008 - Endocrine Soc Results: Elderly T-allele carriers had decreased plasma insulin responses and
lower disposition index, whereas insulinogenic index was similar between
genotype groups. Elderly nondiabetic T-allele carriers had increased ... Cited by 11 - Related articles - All 3 versions
