SA Summers - Progress in Lipid Research, 2006 - Elsevier Obesity predisposes individuals to the development of insulin resistance in skeletal muscle and
the liver, and researchers have recently proposed two mechanisms by which excess adiposity
antagonizes insulin action in peripheral tissues. First, when adipocytes exceed their ... Cited by 114 - Related articles - All 3 versions
- ►physiology.org N Jessen, LJ Goodyear - Journal of Applied Physiology, 2005 - Am Physiological Soc Contracting skeletal muscles acutely increases glucose transport in both healthy individuals
and in people with Type 2 diabetes, and regular physical exercise is a cornerstone in the treatment
of the disease. Glucose transport in skeletal muscle is dependent on the translocation of ... Cited by 95 - Related articles - BL Direct - All 9 versions
HF Kramer, CA Witczak, N Fujii, N Jessen, EB Taylor, … - Diabetes, 2006 - Am Diabetes Assoc Insulin and contraction increase GLUT4 translocation in skeletal muscle via distinct signaling
mechanisms. Akt substrate of 160 kDa (AS160) mediates insulin-stimulated GLUT4 translocation
in L6 myotubes, presumably through activation of Akt. Using in vivo, in vitro, and in situ ... Cited by 85 - Related articles - BL Direct - All 6 versions
JT Treebak, S Glund, A Deshmukh, DK Klein, YC Long, … - Diabetes, 2006 - Am Diabetes Assoc AMP-activated protein kinase (AMPK) is a heterotrimeric protein that regulates glucose transport
mediated by cellular stress or pharmacological agonists such as 5-aminoimidazole-4-carboxamide
1 β-d-ribonucleoside (AICAR). AS160, a Rab GTPase-activating protein, provides a ... Cited by 83 - Related articles - BL Direct - All 7 versions
- ►physiology.org FSL Thong, CB Dugani, A Klip - Physiology, 2005 - cat.inist.fr Insulin stimulation of glucose uptake into skeletal muscle and adipose tissues is achieved by
accelerating glucose transporter GLUT 4 exocytosis from intracellular compartments to the plasma
membrane and minimally reducingits endocytosis. The round trip of GLUT 4 is intricately ... Cited by 79 - Related articles - BL Direct - All 4 versions
HKR Karlsson, JR Zierath, S Kane, A Krook, GE … - Diabetes, 2005 - Am Diabetes Assoc AS160 is a newly described substrate for the protein kinase Akt that links insulin signaling and
GLUT4 trafficking. In this study, we determined the expression of and in vivo insulin action on
AS160 in human skeletal muscle. In addition, we compared the effect of physiological ... Cited by 78 - Related articles - All 5 versions
- ►uc.pt [PDF] RT Watson, JE Pessin - Trends in biochemical sciences, 2006 - Elsevier Upon binding and activating its cell-surface receptor, insulin triggers signaling cascades that
regulate many cellular processes. Regarding glucose homeostasis, insulin suppresses hepatic
glucose production and increases glucose transport into muscle and adipose tissues. At ... Cited by 69 - Related articles - All 8 versions
HF Kramer, CA Witczak, EB Taylor, N Fujii, MF … - Journal of Biological …, 2006 - ASBMB Insulin and contraction are potent stimulators of GLUT4 translocation and increase skeletal muscle
glucose uptake. We recently identified the Rab GTPase-activating protein (GAP) AS160 as a
putative point of convergence linking distinct upstream signaling cascades induced by ... Cited by 64 - Related articles - All 6 versions
- ►physiology.org AJ Rose, EA Richter - Physiology, 2005 - Am Physiological Soc During dynamic exercise, the turnover of ATP in skeletal muscle increases greatly and is fuelled
by the catabolism of carbohydrates (intramuscular glycogen, blood glucose) and fatty acids
(intramuscular triglycerides, blood lipids). During exercise in the postabsorptive state, the ... Cited by 60 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org A Sriwijitkamol, DK Coletta, E Wajcberg, GB Balbontin, … - Diabetes, 2007 - Am Diabetes Assoc Activation of AMP-activated protein kinase (AMPK) by exercise induces several cellular processes
in muscle. Exercise activation of AMPK is unaffected in lean (BMI ∼25 kg/m 2 ) subjects with
type 2 diabetes. However, most type 2 diabetic subjects are obese (BMI >30 kg/m 2 ), and ... Cited by 51 - Related articles - BL Direct - All 4 versions
