- ►nih.gov K Morino, KF Petersen, S Dufour, D Befroy, J … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig To further explore the nature of the mitochondrial dysfunction and insulin
resistance that occur in the muscle of young, lean, normoglycemic,
insulin-resistant offspring of parents with type 2 diabetes (IR offspring), ... Cited by 165 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org K Morino, KF Petersen, GI Shulman - Diabetes, 2006 - Am Diabetes Assoc Recent studies using magnetic resonance spectroscopy have shown that decreased
insulin-stimulated muscle glycogen synthesis due to a defect in
insulin-stimulated glucose transport activity is a major factor in the ... Cited by 123 - Related articles - BL Direct - All 5 versions
- ►physiology.org DB Savage, KF Petersen, GI Shulman - Physiological reviews, 2007 - Am Physiological Soc Although abnormal glucose metabolism defines type 2 diabetes mellitus (T2DM) and
accounts for many of its symptoms and complications, efforts to understand the
pathogenesis of T2DM are increasingly focused on disordered lipid ... Cited by 111 - Related articles - BL Direct - All 5 versions
- ►ahajournals.org YH Yu, HN Ginsberg - Circulation research, 2005 - Am Heart Assoc For many years adipose tissue was viewed as the site where excess energy was
stored, in the form of triglycerides (TGs), and where that energy, when needed
elsewhere in the body, was released in the form of fatty acids (FAs). ... Cited by 104 - Related articles - All 7 versions
- ►jbc.org TR Koves, P Li, J An, T Akimoto, D Slentz, … - Journal of Biological Chemistry, 2005 - ASBMB Peroxisome proliferator-activated receptor- co-activator 1 (PGC1 ) is a
promiscuous co-activator that plays a key role in regulating mitochondrial
biogenesis and fuel homeostasis. Emergent evidence links decreased skeletal ... Cited by 104 - Related articles - BL Direct - All 4 versions
DA Hood, I Irrcher, V Ljubicic, AM Joseph - Journal of experimental biology, 2006 - jeb.biologists.org Skeletal muscle is a highly malleable tissue, capable of pronounced metabolic
and morphological adaptations in response to contractile activity (ie exercise).
Each bout of contractile activity results in a coordinated alteration in ... Cited by 95 - Related articles - BL Direct - All 4 versions
- ►physiology.org B Kiens - Physiological reviews, 2006 - Am Physiological Soc Lipids as fuel for energy provision originate from different sources:
albumin-bound long-chain fatty acids (LCFA) in the blood plasma, circulating
very-low-density lipoproteins-triacylglycerols (VLDL-TG), fatty acids from ... Cited by 79 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org GK Bandyopadhyay, JG Yu, J Ofrecio, JM … - Diabetes, 2006 - Am Diabetes Assoc Increased accumulation of fatty acids and their derivatives can impair
insulin-stimulated glucose disposal by skeletal muscle. To characterize the
nature of the defects in lipid metabolism and to evaluate the effects of ... Cited by 78 - Related articles - BL Direct - All 5 versions
- ►physoc.org PD Taylor, L Poston - Experimental Physiology, 2007 - Physiological Soc Converging lines of evidence from epidemiological studies and animal models now
indicate that the origins of obesity and related metabolic disorders lie not
only in the interaction between genes and traditional adult risk factors, ... Cited by 69 - Related articles - BL Direct - All 9 versions
- ►shouxi.net N Turner, CR Bruce, SM Beale, KL Hoehn, T … - Diabetes, 2007 - Am Diabetes Assoc A reduced capacity for mitochondrial fatty acid oxidation in skeletal muscle has
been proposed as a major factor leading to the accumulation of intramuscular
lipids and their subsequent deleterious effects on insulin action. Here, we ... Cited by 60 - Related articles - BL Direct - All 5 versions
