- ►jimmunol.org M Miyara, Z Amoura, C Parizot, C Badoual, K … - The Journal of Immunology, 2005 - Am Assoc Immnol The immune defect that could account for the multisystemic involvement that
characterizes systemic lupus erythematosus (SLE) remains unknown. We
hypothesized that iterative disease flares correspond to a recurrent defect ... Cited by 138 - Related articles - BL Direct - All 6 versions
JA Bluestone, Q Tang - Current opinion in immunology, 2005 - Elsevier Any scientist opening up an immunology journal today will observe immediately
that suppressor T cells, renamed 'regulatory T cells' (Tregs) have become a
central concept in the immunology lexicon. Hundreds of Treg publications ... Cited by 137 - Related articles - All 6 versions
- ►nih.gov R Bacchetta, L Passerini, E Gambineri, M Dai, … - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig 1 San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Milan, Italy. 2
Pediatrics Department, “A. Meyer” Children's Hospital, University of
Florence, Florence, Italy. 3 Department of Surgery, University of British ... Cited by 132 - Related articles - BL Direct - All 11 versions
- ►nih.gov A Zanin-Zhorov, L Cahalon, G Tal, R Margalit, … - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig CD4 + CD25 + Tregs regulate immunity, but little is known about their own
regulation. We now report that the human 60-kDa heat shock protein (HSP60) acts
as a costimulator of human Tregs, both CD4 + CD25 int and CD4 + CD25 hi . ... Cited by 132 - Related articles - BL Direct - All 10 versions
- ►hematologylibrary.org DQ Tran, H Ramsey, EM Shevach - Blood, 2007 - bloodjournal.hematologylibrary.org Thymic-derived natural T-regulatory cells (nTregs) are important for the
induction of self-tolerance and the control of autoimmunity. Murine CD4 + CD25
– Foxp3 – cells can be induced to express Foxp3 after T-cell receptor ... Cited by 128 - Related articles - BL Direct - All 4 versions
J Huan, N Culbertson, L Spencer, R … - Journal of neuroscience research, 2005 - interscience.wiley.com Autoimmune diseases such as multiple sclerosis (MS) may result from the failure
of tolerance mechanisms to prevent expansion of pathogenic T cells. Our study is
the first to establish that MS patients have abnormalities in FOXP3 message ... Cited by 118 - Related articles - BL Direct - All 4 versions
Q Tang, JA Bluestone - Immunological reviews, 2006 - interscience.wiley.com Summary: Endowed with the ability to actively suppress an immune response,
regulatory T cells (Tregs) hold the promise of halting ongoing pathogenic
autoimmunity and restoring self-tolerance in patients suffering from ... Cited by 116 - Related articles - BL Direct - All 5 versions
C Baecher-Allan, DA Hafler - Immunological reviews, 2006 - interscience.wiley.com Summary: As self-recognition is fundamental to the efficient operation of the
immune system, a number of mechanisms have evolved to keep this potential
pathologic self-reactivity in check. Thus, even though the majority of ... Cited by 108 - Related articles - BL Direct - All 5 versions
- ►jimmunol.org M Battaglia, A Stabilini, B Migliavacca, J … - The Journal of Immunology, 2006 - Am Assoc Immnol CD4 + CD25 + FOXP3 + T regulatory cells (Tregs) are pivotal for the induction
and maintenance of peripheral tolerance in both mice and humans. Rapamycin has
been shown to promote tolerance in experimental models and to favor CD4 + ... Cited by 100 - Related articles - BL Direct - All 4 versions
R Bacchetta, S Gregori, MG Roncarolo - Autoimmunity Reviews, 2005 - Elsevier The main subsets of CD4 + regulatory T (Tr) cells are the CD4 + CD25 + Tr cells
and the type 1 regulatory (Tr1) cells. Both subsets are essential for the
maintenance of peripheral tolerance. CD4 + CD25 + Tr cells control immune ... Cited by 97 - Related articles - All 2 versions
